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HDAC2 Promotes elF4E Sumoylation and Activates mRNA Translation Gene Specifically.

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Title: HDAC2 Promotes elF4E Sumoylation and Activates mRNA Translation Gene Specifically.
Authors: Xiang Xu1,2, Vatsyayan, Jaya1, Chenxi Gao1, Bakkenist, Christopher J.1,3, Jing Hu1 huj3@upmc.edu
Source: Journal of Biological Chemistry. 6/11/2010, Vol. 285 Issue 24, p18139-18143. 5p. 2 Diagrams, 2 Graphs.
Subjects: Histone deacetylases, Genetic transcription, Messenger RNA, Cell proliferation, Apoptosis, Protein synthesis
Abstract: Histone deacetylases (HDACs) are best known as transcription corepressors through deacetylating histone tails. Here we show that HDAC2 is also involved in cap-dependent mRNA translation by promoting sumoylation of eukaryotic translation initiation factor 4E (eIF4E), which is independent of its deacetylase activity. By stimulating eIF4E sumoylation, HDAC2 induces the formation of the active eukaryotic initiation factor 4F (eIF4F) complex and induces the protein synthesis of a subset of elF4E-responsive genes that are essential for cell proliferation and preventing apoptosis. These data demonstrate that HDAC2 has an unexpected sumoylation-promoting activity and regulates cap-dependent mRNA translation. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Biological Chemistry is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
An: 51698608
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PubTypeId: academicJournal
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  Data: HDAC2 Promotes elF4E Sumoylation and Activates mRNA Translation Gene Specifically.
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  Data: <searchLink fieldCode="AR" term="%22Xiang+Xu%22">Xiang Xu</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Vatsyayan%2C+Jaya%22">Vatsyayan, Jaya</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Chenxi+Gao%22">Chenxi Gao</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Bakkenist%2C+Christopher+J%2E%22">Bakkenist, Christopher J.</searchLink><relatesTo>1,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Jing+Hu%22">Jing Hu</searchLink><relatesTo>1</relatesTo><i> huj3@upmc.edu</i>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Biological+Chemistry%22">Journal of Biological Chemistry</searchLink>. 6/11/2010, Vol. 285 Issue 24, p18139-18143. 5p. 2 Diagrams, 2 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Histone+deacetylases%22">Histone deacetylases</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+transcription%22">Genetic transcription</searchLink><br /><searchLink fieldCode="DE" term="%22Messenger+RNA%22">Messenger RNA</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+proliferation%22">Cell proliferation</searchLink><br /><searchLink fieldCode="DE" term="%22Apoptosis%22">Apoptosis</searchLink><br /><searchLink fieldCode="DE" term="%22Protein+synthesis%22">Protein synthesis</searchLink>
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  Label: Abstract
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  Data: Histone deacetylases (HDACs) are best known as transcription corepressors through deacetylating histone tails. Here we show that HDAC2 is also involved in cap-dependent mRNA translation by promoting sumoylation of eukaryotic translation initiation factor 4E (eIF4E), which is independent of its deacetylase activity. By stimulating eIF4E sumoylation, HDAC2 induces the formation of the active eukaryotic initiation factor 4F (eIF4F) complex and induces the protein synthesis of a subset of elF4E-responsive genes that are essential for cell proliferation and preventing apoptosis. These data demonstrate that HDAC2 has an unexpected sumoylation-promoting activity and regulates cap-dependent mRNA translation. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Biological Chemistry is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1074/jbc.C110.131599
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      – Code: eng
        Text: English
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        PageCount: 5
        StartPage: 18139
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      – SubjectFull: Histone deacetylases
        Type: general
      – SubjectFull: Genetic transcription
        Type: general
      – SubjectFull: Messenger RNA
        Type: general
      – SubjectFull: Cell proliferation
        Type: general
      – SubjectFull: Apoptosis
        Type: general
      – SubjectFull: Protein synthesis
        Type: general
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      – TitleFull: HDAC2 Promotes elF4E Sumoylation and Activates mRNA Translation Gene Specifically.
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            NameFull: Vatsyayan, Jaya
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            NameFull: Chenxi Gao
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            NameFull: Bakkenist, Christopher J.
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            NameFull: Jing Hu
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              Text: 6/11/2010
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              Y: 2010
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