Synthesis and Comparative Study on the Reactivity of Peptidyl-Type Phosphinic Esters....
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| Title: | Synthesis and Comparative Study on the Reactivity of Peptidyl-Type Phosphinic Esters.... |
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| Authors: | Georgiadis, Dimitris, Dive, Vincent, Yiotakis, Athanasios |
| Source: | Journal of Organic Chemistry. 10/5/2001, Vol. 66 Issue 20, p6604. 7p. 6 Diagrams, 4 Charts. |
| Subjects: | Esters, Phosphine, Reactivity (Chemistry) |
| Abstract: | Examines the reactivity of peptidyl-type phosphinic esters under conventional deprotection conditions. Use of the phosphinic analogue of Cbz-Phe-Gly-OEt as a template; Effect of ateric hindrance on the rate of hydrolysis of beta-carboxyphosphinates; Factors affecting the occurrence of the acceleration of phosphinate cleavage. |
| Database: | Engineering Source |
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