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Application of continuous supercritical anti-solvents for rapid recrystallization and purification of zeaxanthin dipalmitates from de-glycosides of Lycium barbarum fruits

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Title: Application of continuous supercritical anti-solvents for rapid recrystallization and purification of zeaxanthin dipalmitates from de-glycosides of Lycium barbarum fruits
Authors: Chang, Li-Pin1, Cheng, Jia-Hui1, Hsu, Shih-Lan2, Liau, Bing-Chung1, Wu, Tzong-Ming3, Chang, Chieh-Ming J.1 cmchang@dragon.nchu.edu.tw
Source: Journal of Supercritical Fluids. Jun2011, Vol. 57 Issue 2, p155-161. 7p.
Subjects: Supercritical fluids, Solvents, Glycosides, Lycium chinense, Rhodopsin, Epithelial cells, Oxidation, Acetone, Recrystallization (Chemistry)
Abstract: Abstract: This study employed column elution fractionation coupled with supercritical anti-solvent recrystallization to isolate the purest zeaxanthin dipalmitates (ZP), one of the eye-protecting compounds in the Lycium barbarum fruits. The amount of ZP increased to 983mg/g in liquid anti-solvent precipitates with 29.1% recovery and increased to 929mg/g in supercritical anti-solvent precipitates with 59.6% recovery, respectively from the ultrasonic acetone extract. Experimental data showed that supercritical anti-solvent recrystallization is feasible in producing platelet type precipitates within a few minutes. These ZP compounds exhibit anti-oxidative abilities by proliferating human adult retinal pigment epithelial cells (from 22% to 31%); though it was a meager increase when compared to those of algal 95% zeaxanthin (from 43% to 94%). [Copyright &y& Elsevier]
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Database: Engineering Source
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Abstract:Abstract: This study employed column elution fractionation coupled with supercritical anti-solvent recrystallization to isolate the purest zeaxanthin dipalmitates (ZP), one of the eye-protecting compounds in the Lycium barbarum fruits. The amount of ZP increased to 983mg/g in liquid anti-solvent precipitates with 29.1% recovery and increased to 929mg/g in supercritical anti-solvent precipitates with 59.6% recovery, respectively from the ultrasonic acetone extract. Experimental data showed that supercritical anti-solvent recrystallization is feasible in producing platelet type precipitates within a few minutes. These ZP compounds exhibit anti-oxidative abilities by proliferating human adult retinal pigment epithelial cells (from 22% to 31%); though it was a meager increase when compared to those of algal 95% zeaxanthin (from 43% to 94%). [Copyright &y& Elsevier]
ISSN:08968446
DOI:10.1016/j.supflu.2011.02.008