Bibliographic Details
| Title: |
Functional connectivity in the pharmacologically activated brain: Resolving networks of correlated responses to d-amphetamine. |
| Authors: |
Schwarz, Adam J.1, Gozzi, Alessandro1, Reese, Torsten1, Bifone, Angelo1 |
| Source: |
Magnetic Resonance in Medicine. Apr2007, Vol. 57 Issue 4, p704-713. 10p. |
| Abstract: |
We investigated the functional connectivity structure underlying the widespread relative cerebral blood volume (rCBV) response to d-amphetamine in the rat brain by systematically analyzing the intersubject correlations between the response amplitudes in 48 atlas-defined brain structures. A cluster analysis resolved three distinct networks of brain regions that exhibited closely coupled responses: one corresponding to primary dopamine projections from the midbrain to the striatum, a second consisting predominantly of forebrain cortical and basal ganglia regions that share a widespread correlation pattern resembling the univariate group response, and a third including structures in the periventricular dopamine system. These results suggest that different functional networks underlie the brain's response to d-amphetamine. This approach may provide important new insights regarding the central systems that underlie pharmacological action. Magn Reson Med 57:704-713, 2007. © 2007 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR] |
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| Database: |
Engineering Source |
