Functional connectivity in the pharmacologically activated brain: Resolving networks of correlated responses to d-amphetamine.
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| Title: | Functional connectivity in the pharmacologically activated brain: Resolving networks of correlated responses to d-amphetamine. |
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| Authors: | Schwarz, Adam J.1, Gozzi, Alessandro1, Reese, Torsten1, Bifone, Angelo1 |
| Source: | Magnetic Resonance in Medicine. Apr2007, Vol. 57 Issue 4, p704-713. 10p. |
| Abstract: | We investigated the functional connectivity structure underlying the widespread relative cerebral blood volume (rCBV) response to d-amphetamine in the rat brain by systematically analyzing the intersubject correlations between the response amplitudes in 48 atlas-defined brain structures. A cluster analysis resolved three distinct networks of brain regions that exhibited closely coupled responses: one corresponding to primary dopamine projections from the midbrain to the striatum, a second consisting predominantly of forebrain cortical and basal ganglia regions that share a widespread correlation pattern resembling the univariate group response, and a third including structures in the periventricular dopamine system. These results suggest that different functional networks underlie the brain's response to d-amphetamine. This approach may provide important new insights regarding the central systems that underlie pharmacological action. Magn Reson Med 57:704-713, 2007. © 2007 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR] |
| Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 63346939 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/mrm.21179 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 10 StartPage: 704 Titles: – TitleFull: Functional connectivity in the pharmacologically activated brain: Resolving networks of correlated responses to d-amphetamine. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Schwarz, Adam J. – PersonEntity: Name: NameFull: Gozzi, Alessandro – PersonEntity: Name: NameFull: Reese, Torsten – PersonEntity: Name: NameFull: Bifone, Angelo IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 04 Text: Apr2007 Type: published Y: 2007 Identifiers: – Type: issn-print Value: 07403194 Numbering: – Type: volume Value: 57 – Type: issue Value: 4 Titles: – TitleFull: Magnetic Resonance in Medicine Type: main |
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