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Dose estimation in B16 tumour bearing mice for future irradiation in the thermal column of the TRIGA reactor after B/Gd/LDL adduct infusion

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Title: Dose estimation in B16 tumour bearing mice for future irradiation in the thermal column of the TRIGA reactor after B/Gd/LDL adduct infusion
Authors: Protti, N.1,2 nicoletta.protti@pv.infn.it, Ballarini, F.1,2, Bortolussi, S.1,2, Bruschi, P.1, Stella, S.1,2, Geninatti, S.3, Alberti, D.3, Aime, S.3, Altieri, S.1,2
Source: Applied Radiation & Isotopes. Dec2011, Vol. 69 Issue 12, p1842-1845. 4p.
Subjects: Laboratory mice, Irradiation, Infusion therapy, Boron isotopes, Low density lipoproteins, Gadolinium, Boric acid, Therapeutics
Abstract: Abstract: To test the efficacy of a new 10B-vector compound, the B/Gd/LDL adduct synthesised at Torino University, in vivo irradiations of murine tumours are in progress at the TRIGA Mark II reactor of the Pavia University. A localised B16 melanoma tumour is generated in C57BL/6 mice and subsequently infused with the adduct. During the irradiation, the mouse will be put in a shield to protect the whole body except the tumour in the back-neck area. To optimise the treatment set-up, MCNP simulations were performed. A very simplified mouse model was built using MCNP geometry capabilities, as well as the geometry of the shield made of 99% 10B enriched boric acid. A hole in the shield is foreseen in correspondence of the back-neck region. Many configurations of the shield were tested in terms of neutron flux, dose distribution and mean induced activity in the tumour region and in the radiosensitive organs of the mouse. In the final set-up, up to five mice can be treated simultaneously in the reactor thermal column and the neutron fluence in the tumour region for 10min of irradiation is of about 5×1012 cm−2. [Copyright &y& Elsevier]
Copyright of Applied Radiation & Isotopes is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 67137321
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Dose estimation in B16 tumour bearing mice for future irradiation in the thermal column of the TRIGA reactor after B/Gd/LDL adduct infusion
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  Data: <searchLink fieldCode="AR" term="%22Protti%2C+N%2E%22">Protti, N.</searchLink><relatesTo>1,2</relatesTo><i> nicoletta.protti@pv.infn.it</i><br /><searchLink fieldCode="AR" term="%22Ballarini%2C+F%2E%22">Ballarini, F.</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Bortolussi%2C+S%2E%22">Bortolussi, S.</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Bruschi%2C+P%2E%22">Bruschi, P.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Stella%2C+S%2E%22">Stella, S.</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Geninatti%2C+S%2E%22">Geninatti, S.</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Alberti%2C+D%2E%22">Alberti, D.</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Aime%2C+S%2E%22">Aime, S.</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Altieri%2C+S%2E%22">Altieri, S.</searchLink><relatesTo>1,2</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Applied+Radiation+%26+Isotopes%22">Applied Radiation & Isotopes</searchLink>. Dec2011, Vol. 69 Issue 12, p1842-1845. 4p.
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  Data: <searchLink fieldCode="DE" term="%22Laboratory+mice%22">Laboratory mice</searchLink><br /><searchLink fieldCode="DE" term="%22Irradiation%22">Irradiation</searchLink><br /><searchLink fieldCode="DE" term="%22Infusion+therapy%22">Infusion therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Boron+isotopes%22">Boron isotopes</searchLink><br /><searchLink fieldCode="DE" term="%22Low+density+lipoproteins%22">Low density lipoproteins</searchLink><br /><searchLink fieldCode="DE" term="%22Gadolinium%22">Gadolinium</searchLink><br /><searchLink fieldCode="DE" term="%22Boric+acid%22">Boric acid</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutics%22">Therapeutics</searchLink>
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  Data: Abstract: To test the efficacy of a new 10B-vector compound, the B/Gd/LDL adduct synthesised at Torino University, in vivo irradiations of murine tumours are in progress at the TRIGA Mark II reactor of the Pavia University. A localised B16 melanoma tumour is generated in C57BL/6 mice and subsequently infused with the adduct. During the irradiation, the mouse will be put in a shield to protect the whole body except the tumour in the back-neck area. To optimise the treatment set-up, MCNP simulations were performed. A very simplified mouse model was built using MCNP geometry capabilities, as well as the geometry of the shield made of 99% 10B enriched boric acid. A hole in the shield is foreseen in correspondence of the back-neck region. Many configurations of the shield were tested in terms of neutron flux, dose distribution and mean induced activity in the tumour region and in the radiosensitive organs of the mouse. In the final set-up, up to five mice can be treated simultaneously in the reactor thermal column and the neutron fluence in the tumour region for 10min of irradiation is of about 5×1012 cm−2. [Copyright &y& Elsevier]
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  Data: <i>Copyright of Applied Radiation & Isotopes is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1016/j.apradiso.2011.02.045
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        Text: English
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      – SubjectFull: Irradiation
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      – SubjectFull: Infusion therapy
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      – SubjectFull: Boron isotopes
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      – SubjectFull: Therapeutics
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      – TitleFull: Dose estimation in B16 tumour bearing mice for future irradiation in the thermal column of the TRIGA reactor after B/Gd/LDL adduct infusion
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              M: 12
              Text: Dec2011
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