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Set-up and calibration of a method to measure 10B concentration in biological samples by neutron autoradiography

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Title: Set-up and calibration of a method to measure 10B concentration in biological samples by neutron autoradiography
Authors: Gadan, M.A.1,2, Bortolussi, S.2,3 silva.bortolussi@pv.infn.it, Postuma, I.2, Ballarini, F.2,3, Bruschi, P.2, Protti, N.2,3, Santoro, D.2,3, Stella, S.2,3, Cansolino, L.4, Clerici, A.4, Ferrari, C.4, Zonta, A.4, Zonta, C.4, Altieri, S.2,3
Source: Nuclear Instruments & Methods in Physics Research Section B. Mar2012, Vol. 274, p51-56. 6p.
Subjects: Calibration, Neutrons, Autoradiography, Boron-neutron capture therapy, Tumor treatment, Measure theory
Abstract: Abstract: A selective uptake of boron in the tumor is the base of Boron Neutron Capture Therapy, which can destroy the tumor substantially sparing the normal tissue. In order to deliver a lethal dose to the tumor, keeping the dose absorbed by normal tissues below the tolerance level, it is mandatory to know the 10B concentration present in each kind of tissue at the moment of irradiation. This work presents the calibration procedure adopted for a boron concentration measurement method based on neutron autoradiography, where biological samples are deposited on sensitive films and irradiated in the thermal column of the TRIGA reactor (University of Pavia). The latent tracks produced in the film by the charged particles coming from the neutron capture in 10B are made visible by a proper etching, allowing the measurement of the track density. A calibration procedure with standard samples provides curves of track density as a function of boron concentration, to be used in the measurement of biological samples. In this paper, the bulk etch rate parameter and the calibration curves obtained for both liquid samples and biological tissues with known boron concentration are presented. A bulk etch rate value of (1.64±0.02)μm/h and a linear dependence with etching time were found. The plots representing the track density versus the boron concentration in a range between 5 and 50μg/g (ppm) are linear, with an angular coefficient of (1.614±0.169)·10−3 tracks/(μm2 ppm) for liquids and (1.598±0.097)·10−2 tracks/(μm2 ppm) for tissues. [Copyright &y& Elsevier]
Copyright of Nuclear Instruments & Methods in Physics Research Section B is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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DbLabel: Engineering Source
An: 71406280
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  Data: Set-up and calibration of a method to measure <superscript>10</superscript>B concentration in biological samples by neutron autoradiography
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  Data: <searchLink fieldCode="AR" term="%22Gadan%2C+M%2EA%2E%22">Gadan, M.A.</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Bortolussi%2C+S%2E%22">Bortolussi, S.</searchLink><relatesTo>2,3</relatesTo><i> silva.bortolussi@pv.infn.it</i><br /><searchLink fieldCode="AR" term="%22Postuma%2C+I%2E%22">Postuma, I.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Ballarini%2C+F%2E%22">Ballarini, F.</searchLink><relatesTo>2,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Bruschi%2C+P%2E%22">Bruschi, P.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Protti%2C+N%2E%22">Protti, N.</searchLink><relatesTo>2,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Santoro%2C+D%2E%22">Santoro, D.</searchLink><relatesTo>2,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Stella%2C+S%2E%22">Stella, S.</searchLink><relatesTo>2,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Cansolino%2C+L%2E%22">Cansolino, L.</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Clerici%2C+A%2E%22">Clerici, A.</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Ferrari%2C+C%2E%22">Ferrari, C.</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Zonta%2C+A%2E%22">Zonta, A.</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Zonta%2C+C%2E%22">Zonta, C.</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Altieri%2C+S%2E%22">Altieri, S.</searchLink><relatesTo>2,3</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Nuclear+Instruments+%26+Methods+in+Physics+Research+Section+B%22">Nuclear Instruments & Methods in Physics Research Section B</searchLink>. Mar2012, Vol. 274, p51-56. 6p.
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  Data: <searchLink fieldCode="DE" term="%22Calibration%22">Calibration</searchLink><br /><searchLink fieldCode="DE" term="%22Neutrons%22">Neutrons</searchLink><br /><searchLink fieldCode="DE" term="%22Autoradiography%22">Autoradiography</searchLink><br /><searchLink fieldCode="DE" term="%22Boron-neutron+capture+therapy%22">Boron-neutron capture therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Tumor+treatment%22">Tumor treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Measure+theory%22">Measure theory</searchLink>
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  Data: Abstract: A selective uptake of boron in the tumor is the base of Boron Neutron Capture Therapy, which can destroy the tumor substantially sparing the normal tissue. In order to deliver a lethal dose to the tumor, keeping the dose absorbed by normal tissues below the tolerance level, it is mandatory to know the 10B concentration present in each kind of tissue at the moment of irradiation. This work presents the calibration procedure adopted for a boron concentration measurement method based on neutron autoradiography, where biological samples are deposited on sensitive films and irradiated in the thermal column of the TRIGA reactor (University of Pavia). The latent tracks produced in the film by the charged particles coming from the neutron capture in 10B are made visible by a proper etching, allowing the measurement of the track density. A calibration procedure with standard samples provides curves of track density as a function of boron concentration, to be used in the measurement of biological samples. In this paper, the bulk etch rate parameter and the calibration curves obtained for both liquid samples and biological tissues with known boron concentration are presented. A bulk etch rate value of (1.64±0.02)μm/h and a linear dependence with etching time were found. The plots representing the track density versus the boron concentration in a range between 5 and 50μg/g (ppm) are linear, with an angular coefficient of (1.614±0.169)·10−3 tracks/(μm2 ppm) for liquids and (1.598±0.097)·10−2 tracks/(μm2 ppm) for tissues. [Copyright &y& Elsevier]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Nuclear Instruments & Methods in Physics Research Section B is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1016/j.nimb.2011.11.043
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        Text: English
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        PageCount: 6
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      – SubjectFull: Calibration
        Type: general
      – SubjectFull: Neutrons
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      – SubjectFull: Autoradiography
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