Bibliographic Details
| Title: |
A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression. |
| Authors: |
Ito, Kazuhiro, Sam Lim, Caramori, Gaetano, Cosio, Borja, Chung, K. Fan, Adcock, Ian M., Barnes, Peter J. |
| Source: |
Proceedings of the National Academy of Sciences of the United States of America. 6/25/2002, Vol. 99 Issue 13, p8926. 6p. 2 Diagrams, 14 Graphs. |
| Subjects: |
Histone deacetylases, Epithelial cells, Theophylline, Gene expression |
| Abstract: |
Investigates the enhancement of histone deacetylases activity in epithelial cells and macrophages by low-dose theophylline to decrease inflammatory gene expression. Effects of theophylline on clinical parameters; Use of chromatin immunoprecipitation assay; Interaction of theophylline with dexamethasone. |
| Database: |
Engineering Source |
