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A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression.

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Title: A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression.
Authors: Ito, Kazuhiro, Sam Lim, Caramori, Gaetano, Cosio, Borja, Chung, K. Fan, Adcock, Ian M., Barnes, Peter J.
Source: Proceedings of the National Academy of Sciences of the United States of America. 6/25/2002, Vol. 99 Issue 13, p8926. 6p. 2 Diagrams, 14 Graphs.
Subjects: Histone deacetylases, Epithelial cells, Theophylline, Gene expression
Abstract: Investigates the enhancement of histone deacetylases activity in epithelial cells and macrophages by low-dose theophylline to decrease inflammatory gene expression. Effects of theophylline on clinical parameters; Use of chromatin immunoprecipitation assay; Interaction of theophylline with dexamethasone.
Database: Engineering Source
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  Availability: 0
Header DbId: egs
DbLabel: Engineering Source
An: 7218973
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression.
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  Data: <searchLink fieldCode="AR" term="%22Ito%2C+Kazuhiro%22">Ito, Kazuhiro</searchLink><br /><searchLink fieldCode="AR" term="%22Sam+Lim%22">Sam Lim</searchLink><br /><searchLink fieldCode="AR" term="%22Caramori%2C+Gaetano%22">Caramori, Gaetano</searchLink><br /><searchLink fieldCode="AR" term="%22Cosio%2C+Borja%22">Cosio, Borja</searchLink><br /><searchLink fieldCode="AR" term="%22Chung%2C+K%2E+Fan%22">Chung, K. Fan</searchLink><br /><searchLink fieldCode="AR" term="%22Adcock%2C+Ian+M%2E%22">Adcock, Ian M.</searchLink><br /><searchLink fieldCode="AR" term="%22Barnes%2C+Peter+J%2E%22">Barnes, Peter J.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink>. 6/25/2002, Vol. 99 Issue 13, p8926. 6p. 2 Diagrams, 14 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Histone+deacetylases%22">Histone deacetylases</searchLink><br /><searchLink fieldCode="DE" term="%22Epithelial+cells%22">Epithelial cells</searchLink><br /><searchLink fieldCode="DE" term="%22Theophylline%22">Theophylline</searchLink><br /><searchLink fieldCode="DE" term="%22Gene+expression%22">Gene expression</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Investigates the enhancement of histone deacetylases activity in epithelial cells and macrophages by low-dose theophylline to decrease inflammatory gene expression. Effects of theophylline on clinical parameters; Use of chromatin immunoprecipitation assay; Interaction of theophylline with dexamethasone.
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=7218973
RecordInfo BibRecord:
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    Identifiers:
      – Type: doi
        Value: 10.1073/pnas.132556899
    Languages:
      – Code: eng
        Text: English
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        PageCount: 6
        StartPage: 8926
    Subjects:
      – SubjectFull: Histone deacetylases
        Type: general
      – SubjectFull: Epithelial cells
        Type: general
      – SubjectFull: Theophylline
        Type: general
      – SubjectFull: Gene expression
        Type: general
    Titles:
      – TitleFull: A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression.
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          Name:
            NameFull: Ito, Kazuhiro
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            NameFull: Sam Lim
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            NameFull: Caramori, Gaetano
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            NameFull: Chung, K. Fan
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            – D: 25
              M: 06
              Text: 6/25/2002
              Type: published
              Y: 2002
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              Value: 99
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              Value: 13
          Titles:
            – TitleFull: Proceedings of the National Academy of Sciences of the United States of America
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