A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression.
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| Title: | A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression. |
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| Authors: | Ito, Kazuhiro, Sam Lim, Caramori, Gaetano, Cosio, Borja, Chung, K. Fan, Adcock, Ian M., Barnes, Peter J. |
| Source: | Proceedings of the National Academy of Sciences of the United States of America. 6/25/2002, Vol. 99 Issue 13, p8926. 6p. 2 Diagrams, 14 Graphs. |
| Subjects: | Histone deacetylases, Epithelial cells, Theophylline, Gene expression |
| Abstract: | Investigates the enhancement of histone deacetylases activity in epithelial cells and macrophages by low-dose theophylline to decrease inflammatory gene expression. Effects of theophylline on clinical parameters; Use of chromatin immunoprecipitation assay; Interaction of theophylline with dexamethasone. |
| Database: | Engineering Source |
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