Bibliographic Details
| Title: |
Antiinflammatory effect of low-level laser therapy on Staphylococcus epidermidis endophthalmitis in rabbits. |
| Authors: |
Ma, Wen-jiang1, Li, Xiao-rong1, Li, Ying-xin2 yingxinli@tijmu.edu.cn, Xue, Zhi-xiao2, Yin, Hui-juan2, Ma, Hui2 |
| Source: |
Lasers in Medical Science. May2012, Vol. 27 Issue 3, p585-591. 7p. |
| Subjects: |
Neutrophils, Anti-inflammatory agents, Medical lasers, Eye inflammation, Staphylococcus epidermidis, Laboratory rabbits, Vancomycin, Therapeutics |
| Abstract: |
A rabbit model of endophthalmitis was established to evaluate the antiinflammatory effect of low-level laser therapy (LLLT) as an adjunct to treatment for Staphylococcus epidermidis endophthalmitis. Rabbits were randomly divided into three groups to receive intravitreal injections into their left eye: group A received 0.5 mg vancomycin (100 μl), group B received 0.5 mg vancomycin + 0.2 mg dexamethasone (100 μl), and group C received 0.5 mg vancomycin (100 μl) and continuous wave semiconductor laser irradiation (10 mW, λ = 632 nm) focused on the pupil. Slit lamp examination and B-mode ultrasonography were conducted to evaluate the symptoms of endophthalmitis. Polymorphonuclear cells and tumour necrosis factor alpha (TNF-α) in aqueous fluid were measured at 0 h, and 1, 2, 3, 7 and 15 days. A histology test was conducted at 15 days. B-mode ultrasonography and histology revealed that groups B and C had less inflammation than group A at 15 days. Groups B and C had fewer polymorphonuclear cells and lower levels of TNF-α in aqueous fluid than group A at 2, 3 and 7 days ( P < 0.05). There was no significant difference between groups B and C ( P > 0.05). There was no significant difference between groups A, B and C at 15 days ( P > 0.05). As an adjunct to vancomycin therapy to treat S. epidermidis endophthalmitis, LLLT has an antiinflammatory effect similar to that of dexamethasone. [ABSTRACT FROM AUTHOR] |
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| Database: |
Engineering Source |
