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Antiinflammatory effect of low-level laser therapy on Staphylococcus epidermidis endophthalmitis in rabbits.

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Title: Antiinflammatory effect of low-level laser therapy on Staphylococcus epidermidis endophthalmitis in rabbits.
Authors: Ma, Wen-jiang1, Li, Xiao-rong1, Li, Ying-xin2 yingxinli@tijmu.edu.cn, Xue, Zhi-xiao2, Yin, Hui-juan2, Ma, Hui2
Source: Lasers in Medical Science. May2012, Vol. 27 Issue 3, p585-591. 7p.
Subjects: Neutrophils, Anti-inflammatory agents, Medical lasers, Eye inflammation, Staphylococcus epidermidis, Laboratory rabbits, Vancomycin, Therapeutics
Abstract: A rabbit model of endophthalmitis was established to evaluate the antiinflammatory effect of low-level laser therapy (LLLT) as an adjunct to treatment for Staphylococcus epidermidis endophthalmitis. Rabbits were randomly divided into three groups to receive intravitreal injections into their left eye: group A received 0.5 mg vancomycin (100 μl), group B received 0.5 mg vancomycin + 0.2 mg dexamethasone (100 μl), and group C received 0.5 mg vancomycin (100 μl) and continuous wave semiconductor laser irradiation (10 mW, λ = 632 nm) focused on the pupil. Slit lamp examination and B-mode ultrasonography were conducted to evaluate the symptoms of endophthalmitis. Polymorphonuclear cells and tumour necrosis factor alpha (TNF-α) in aqueous fluid were measured at 0 h, and 1, 2, 3, 7 and 15 days. A histology test was conducted at 15 days. B-mode ultrasonography and histology revealed that groups B and C had less inflammation than group A at 15 days. Groups B and C had fewer polymorphonuclear cells and lower levels of TNF-α in aqueous fluid than group A at 2, 3 and 7 days ( P < 0.05). There was no significant difference between groups B and C ( P > 0.05). There was no significant difference between groups A, B and C at 15 days ( P > 0.05). As an adjunct to vancomycin therapy to treat S. epidermidis endophthalmitis, LLLT has an antiinflammatory effect similar to that of dexamethasone. [ABSTRACT FROM AUTHOR]
Copyright of Lasers in Medical Science is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Antiinflammatory effect of low-level laser therapy on Staphylococcus epidermidis endophthalmitis in rabbits.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Ma%2C+Wen-jiang%22&quot;&gt;Ma, Wen-jiang&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Li%2C+Xiao-rong%22&quot;&gt;Li, Xiao-rong&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Li%2C+Ying-xin%22&quot;&gt;Li, Ying-xin&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt;&lt;i&gt; yingxinli@tijmu.edu.cn&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Xue%2C+Zhi-xiao%22&quot;&gt;Xue, Zhi-xiao&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Yin%2C+Hui-juan%22&quot;&gt;Yin, Hui-juan&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Ma%2C+Hui%22&quot;&gt;Ma, Hui&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt;
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Lasers+in+Medical+Science%22&quot;&gt;Lasers in Medical Science&lt;/searchLink&gt;. May2012, Vol. 27 Issue 3, p585-591. 7p.
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– Name: Abstract
  Label: Abstract
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  Data: A rabbit model of endophthalmitis was established to evaluate the antiinflammatory effect of low-level laser therapy (LLLT) as an adjunct to treatment for Staphylococcus epidermidis endophthalmitis. Rabbits were randomly divided into three groups to receive intravitreal injections into their left eye: group A received 0.5 mg vancomycin (100 μl), group B received 0.5 mg vancomycin + 0.2 mg dexamethasone (100 μl), and group C received 0.5 mg vancomycin (100 μl) and continuous wave semiconductor laser irradiation (10 mW, λ = 632 nm) focused on the pupil. Slit lamp examination and B-mode ultrasonography were conducted to evaluate the symptoms of endophthalmitis. Polymorphonuclear cells and tumour necrosis factor alpha (TNF-α) in aqueous fluid were measured at 0 h, and 1, 2, 3, 7 and 15 days. A histology test was conducted at 15 days. B-mode ultrasonography and histology revealed that groups B and C had less inflammation than group A at 15 days. Groups B and C had fewer polymorphonuclear cells and lower levels of TNF-α in aqueous fluid than group A at 2, 3 and 7 days ( P &lt; 0.05). There was no significant difference between groups B and C ( P &gt; 0.05). There was no significant difference between groups A, B and C at 15 days ( P &gt; 0.05). As an adjunct to vancomycin therapy to treat S. epidermidis endophthalmitis, LLLT has an antiinflammatory effect similar to that of dexamethasone. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Lasers in Medical Science is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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        Value: 10.1007/s10103-011-0991-1
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      – Code: eng
        Text: English
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        PageCount: 7
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      – SubjectFull: Neutrophils
        Type: general
      – SubjectFull: Anti-inflammatory agents
        Type: general
      – SubjectFull: Medical lasers
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      – SubjectFull: Eye inflammation
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      – SubjectFull: Staphylococcus epidermidis
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      – SubjectFull: Laboratory rabbits
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              Text: May2012
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