Bibliographic Details
| Title: |
Mangosteen xanthones, α-and γ-mangostins, inhibit allergic mediators in bone marrow-derived mast cell |
| Authors: |
Chae, Hee-Sung1, Oh, Sei-Ryang1, Lee, Hyeong-Kyu1, Joo, Sang Hoon2, Chin, Young-Won3 f2744@dongguk.edu |
| Source: |
Food Chemistry. Sep2012, Vol. 134 Issue 1, p397-400. 4p. |
| Subjects: |
Xanthone, Mangostin, Bone marrow, Mast cells, Inflammatory mediators, Dietary supplements, Interleukin-6, Cyclooxygenase 2, Gene expression |
| Abstract: |
Abstract: Mangosteen (Garcinia mangostana L.), one of top-selling botanical dietary supplements in the USA, has been used as food and folk medicines in southeastern Asia. Herein, α-and γ-mangostins, major constituents of mangosteen, were investigated for their effect on the bone marrow-derived mast cell (BMMC) mediated allergy mechanism induced by phorbol 12-myristate 13-acetate (PMA) plus A23187. α- and γ-mangostins demonstrated to inhibit Interleukin (IL)-6, prostaglandin D2 (PGD2) and leukotriene C4 (LTC4) production as well as degranulation in PMA plus A23187 induced BMMC. Furthermore, α- and γ-mangostins were found to repress cyclooxygenase (COX)-2 expression in the present study. Thus, these results suggest that α- and γ-mangostins may be useful in alleviating mast cell-mediated allergic inflammatory responses. [Copyright &y& Elsevier] |
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| Database: |
Engineering Source |
