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Mangosteen xanthones, α-and γ-mangostins, inhibit allergic mediators in bone marrow-derived mast cell

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Title: Mangosteen xanthones, α-and γ-mangostins, inhibit allergic mediators in bone marrow-derived mast cell
Authors: Chae, Hee-Sung1, Oh, Sei-Ryang1, Lee, Hyeong-Kyu1, Joo, Sang Hoon2, Chin, Young-Won3 f2744@dongguk.edu
Source: Food Chemistry. Sep2012, Vol. 134 Issue 1, p397-400. 4p.
Subjects: Xanthone, Mangostin, Bone marrow, Mast cells, Inflammatory mediators, Dietary supplements, Interleukin-6, Cyclooxygenase 2, Gene expression
Abstract: Abstract: Mangosteen (Garcinia mangostana L.), one of top-selling botanical dietary supplements in the USA, has been used as food and folk medicines in southeastern Asia. Herein, α-and γ-mangostins, major constituents of mangosteen, were investigated for their effect on the bone marrow-derived mast cell (BMMC) mediated allergy mechanism induced by phorbol 12-myristate 13-acetate (PMA) plus A23187. α- and γ-mangostins demonstrated to inhibit Interleukin (IL)-6, prostaglandin D2 (PGD2) and leukotriene C4 (LTC4) production as well as degranulation in PMA plus A23187 induced BMMC. Furthermore, α- and γ-mangostins were found to repress cyclooxygenase (COX)-2 expression in the present study. Thus, these results suggest that α- and γ-mangostins may be useful in alleviating mast cell-mediated allergic inflammatory responses. [Copyright &y& Elsevier]
Copyright of Food Chemistry is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 74500780
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
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  Label: Title
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  Data: Mangosteen xanthones, α-and γ-mangostins, inhibit allergic mediators in bone marrow-derived mast cell
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  Data: <searchLink fieldCode="AR" term="%22Chae%2C+Hee-Sung%22">Chae, Hee-Sung</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Oh%2C+Sei-Ryang%22">Oh, Sei-Ryang</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Lee%2C+Hyeong-Kyu%22">Lee, Hyeong-Kyu</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Joo%2C+Sang+Hoon%22">Joo, Sang Hoon</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Chin%2C+Young-Won%22">Chin, Young-Won</searchLink><relatesTo>3</relatesTo><i> f2744@dongguk.edu</i>
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  Data: <searchLink fieldCode="JN" term="%22Food+Chemistry%22">Food Chemistry</searchLink>. Sep2012, Vol. 134 Issue 1, p397-400. 4p.
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  Data: <searchLink fieldCode="DE" term="%22Xanthone%22">Xanthone</searchLink><br /><searchLink fieldCode="DE" term="%22Mangostin%22">Mangostin</searchLink><br /><searchLink fieldCode="DE" term="%22Bone+marrow%22">Bone marrow</searchLink><br /><searchLink fieldCode="DE" term="%22Mast+cells%22">Mast cells</searchLink><br /><searchLink fieldCode="DE" term="%22Inflammatory+mediators%22">Inflammatory mediators</searchLink><br /><searchLink fieldCode="DE" term="%22Dietary+supplements%22">Dietary supplements</searchLink><br /><searchLink fieldCode="DE" term="%22Interleukin-6%22">Interleukin-6</searchLink><br /><searchLink fieldCode="DE" term="%22Cyclooxygenase+2%22">Cyclooxygenase 2</searchLink><br /><searchLink fieldCode="DE" term="%22Gene+expression%22">Gene expression</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Abstract: Mangosteen (Garcinia mangostana L.), one of top-selling botanical dietary supplements in the USA, has been used as food and folk medicines in southeastern Asia. Herein, α-and γ-mangostins, major constituents of mangosteen, were investigated for their effect on the bone marrow-derived mast cell (BMMC) mediated allergy mechanism induced by phorbol 12-myristate 13-acetate (PMA) plus A23187. α- and γ-mangostins demonstrated to inhibit Interleukin (IL)-6, prostaglandin D2 (PGD2) and leukotriene C4 (LTC4) production as well as degranulation in PMA plus A23187 induced BMMC. Furthermore, α- and γ-mangostins were found to repress cyclooxygenase (COX)-2 expression in the present study. Thus, these results suggest that α- and γ-mangostins may be useful in alleviating mast cell-mediated allergic inflammatory responses. [Copyright &y& Elsevier]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Food Chemistry is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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        Value: 10.1016/j.foodchem.2012.02.075
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      – Code: eng
        Text: English
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        Type: general
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      – SubjectFull: Bone marrow
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      – SubjectFull: Mast cells
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      – SubjectFull: Inflammatory mediators
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      – SubjectFull: Dietary supplements
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      – SubjectFull: Interleukin-6
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      – SubjectFull: Cyclooxygenase 2
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      – SubjectFull: Gene expression
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      – TitleFull: Mangosteen xanthones, α-and γ-mangostins, inhibit allergic mediators in bone marrow-derived mast cell
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            NameFull: Chae, Hee-Sung
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            NameFull: Oh, Sei-Ryang
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              Text: Sep2012
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              Y: 2012
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