Bibliographic Details
| Title: |
Synthesis of 2-C-methylerythritols and 2-C-methylthreitols via enantiodivergent Sharpless dihydroxylation of trisubstituted olefins |
| Authors: |
Ghosh, Shibaji K.1, Butler, Mark S., Lear, Martin J. Martin.Lear@nus.edu.sg |
| Source: |
Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. May2012, Vol. 53 Issue 22, p2706-2708. 3p. |
| Subjects: |
Organic synthesis, Hydroxylation, Alkenes, Anti-infective agents, Phosphates, Stereoisomers |
| Abstract: |
Abstract: The mevalonate-independent pathway (MIP) is an interesting avenue for antimicrobial lead discovery. Here, we present a unified enantioselective synthesis of all four stereoisomers of 2-C-methyltetrol. These are useful building blocks of many bioactive natural products, including 2-C-methylerythritol phosphate (MEP) of the MIP biosynthetic pathway. [Copyright &y& Elsevier] |
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| Database: |
Engineering Source |
