Synthesis of 2-C-methylerythritols and 2-C-methylthreitols via enantiodivergent Sharpless dihydroxylation of trisubstituted olefins
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| Title: | Synthesis of 2-C-methylerythritols and 2-C-methylthreitols via enantiodivergent Sharpless dihydroxylation of trisubstituted olefins |
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| Authors: | Ghosh, Shibaji K.1, Butler, Mark S., Lear, Martin J. Martin.Lear@nus.edu.sg |
| Source: | Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. May2012, Vol. 53 Issue 22, p2706-2708. 3p. |
| Subjects: | Organic synthesis, Hydroxylation, Alkenes, Anti-infective agents, Phosphates, Stereoisomers |
| Abstract: | Abstract: The mevalonate-independent pathway (MIP) is an interesting avenue for antimicrobial lead discovery. Here, we present a unified enantioselective synthesis of all four stereoisomers of 2-C-methyltetrol. These are useful building blocks of many bioactive natural products, including 2-C-methylerythritol phosphate (MEP) of the MIP biosynthetic pathway. [Copyright &y& Elsevier] |
| Copyright of Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 74679400 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Synthesis of 2-C-methylerythritols and 2-C-methylthreitols via enantiodivergent Sharpless dihydroxylation of trisubstituted olefins – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Ghosh%2C+Shibaji+K%2E%22">Ghosh, Shibaji K.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Butler%2C+Mark+S%2E%22">Butler, Mark S.</searchLink><br /><searchLink fieldCode="AR" term="%22Lear%2C+Martin+J%2E%22">Lear, Martin J.</searchLink><i> Martin.Lear@nus.edu.sg</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Tetrahedron+Letters%3A+International+Organ+for+the+Rapid+Publication+of+Preliminary+Communications+in+Organic+Chemistry%22">Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry</searchLink>. May2012, Vol. 53 Issue 22, p2706-2708. 3p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Organic+synthesis%22">Organic synthesis</searchLink><br /><searchLink fieldCode="DE" term="%22Hydroxylation%22">Hydroxylation</searchLink><br /><searchLink fieldCode="DE" term="%22Alkenes%22">Alkenes</searchLink><br /><searchLink fieldCode="DE" term="%22Anti-infective+agents%22">Anti-infective agents</searchLink><br /><searchLink fieldCode="DE" term="%22Phosphates%22">Phosphates</searchLink><br /><searchLink fieldCode="DE" term="%22Stereoisomers%22">Stereoisomers</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Abstract: The mevalonate-independent pathway (MIP) is an interesting avenue for antimicrobial lead discovery. Here, we present a unified enantioselective synthesis of all four stereoisomers of 2-C-methyltetrol. These are useful building blocks of many bioactive natural products, including 2-C-methylerythritol phosphate (MEP) of the MIP biosynthetic pathway. [Copyright &y& Elsevier] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.tetlet.2012.03.071 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 3 StartPage: 2706 Subjects: – SubjectFull: Organic synthesis Type: general – SubjectFull: Hydroxylation Type: general – SubjectFull: Alkenes Type: general – SubjectFull: Anti-infective agents Type: general – SubjectFull: Phosphates Type: general – SubjectFull: Stereoisomers Type: general Titles: – TitleFull: Synthesis of 2-C-methylerythritols and 2-C-methylthreitols via enantiodivergent Sharpless dihydroxylation of trisubstituted olefins Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Ghosh, Shibaji K. – PersonEntity: Name: NameFull: Butler, Mark S. – PersonEntity: Name: NameFull: Lear, Martin J. IsPartOfRelationships: – BibEntity: Dates: – D: 30 M: 05 Text: May2012 Type: published Y: 2012 Identifiers: – Type: issn-print Value: 00404039 Numbering: – Type: volume Value: 53 – Type: issue Value: 22 Titles: – TitleFull: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry Type: main |
| ResultId | 1 |
