View in EDS

Experimental results from a preclinical X-ray phase-contrast CT scanner.

Saved in:
Bibliographic Details
Title: Experimental results from a preclinical X-ray phase-contrast CT scanner.
Authors: Tapfer, Arne1 arne.tapfer@tum.de, Bech, Martin1,2, Velroyen, Astrid1, Meiser, Jan3, Mohr, Jürgen3, Walter, Marco4, Schulz, Joachim4, Pauwels, Bart5, Bruyndonckx, Peter5, Xuan Liu5, Sasov, Alexander5, Pfeiffer, Franz1
Source: Proceedings of the National Academy of Sciences of the United States of America. 9/25/2012, Vol. 109 Issue 39, p15691-15696. 6p.
Subjects: Phase-contrast microscopy, Tomography, Interferometers, Imaging systems, Animal diseases, Quantitative research
Abstract: To explore the future clinical potential of improved soft-tissue visibility with grating-based X-ray phase contrast (PC), we have developed a first preclinical computed tomography (CT) scanner featuring a rotating gantry. The main challenge in the transition from previous bench-top systems to a preclinical scanner are phase artifacts that are caused by minimal changes in the grating align-ment during gantry rotation. In this paper, we present the first experimental results from the system together with an adaptive phase recovery method that corrects for these phase artifacts. Using this method, we show that the scanner can recover quanti-tatively accurate Hounsfield units in attenuation and phase. More-over, we present a first tomography scan of biological tissue with complementary information in attenuation and phase contrast. The present study hence demonstrates the feasibility of grating-based phase contrast with a rotating gantry for the first time and paves the way for future in vivo studies on small animal disease models (in the mid-term future) and human diagnostics applica-tions (in the long-term future). [ABSTRACT FROM AUTHOR]
Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
Description
Abstract:To explore the future clinical potential of improved soft-tissue visibility with grating-based X-ray phase contrast (PC), we have developed a first preclinical computed tomography (CT) scanner featuring a rotating gantry. The main challenge in the transition from previous bench-top systems to a preclinical scanner are phase artifacts that are caused by minimal changes in the grating align-ment during gantry rotation. In this paper, we present the first experimental results from the system together with an adaptive phase recovery method that corrects for these phase artifacts. Using this method, we show that the scanner can recover quanti-tatively accurate Hounsfield units in attenuation and phase. More-over, we present a first tomography scan of biological tissue with complementary information in attenuation and phase contrast. The present study hence demonstrates the feasibility of grating-based phase contrast with a rotating gantry for the first time and paves the way for future in vivo studies on small animal disease models (in the mid-term future) and human diagnostics applica-tions (in the long-term future). [ABSTRACT FROM AUTHOR]
ISSN:00278424
DOI:10.1073/pnas.1207503109