A lattice-based approach to model distraction osteogenesis
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| Title: | A lattice-based approach to model distraction osteogenesis |
|---|---|
| Authors: | Reina-Romo, E.1 erreina@us.es, Gómez-Benito, M.J.2 gomezmj@unizar.es, Domínguez, J.1 jaime@us.es, García-Aznar, J.M.2 jmgaraz@unizar.es |
| Source: | Journal of Biomechanics. Nov2012, Vol. 45 Issue 16, p2736-2742. 7p. |
| Subjects: | Bone growth, Blood-vessel development, Endothelial cells, Ossification, Mathematical continuum, Fick's laws of diffusion, Random walks |
| Abstract: | Abstract: Distraction osteogenesis is a well-known technique in which new bone tissue is created when a distraction displacement is applied through an external frame. This orthopedic process is nowadays focus of intense research, both experimentally and numerically, as there are still many aspects not well understood. The aim of this study is to simulate bone distraction by means of a combined discrete-continuum approach based on a lattice formulation. Existing computational models simulate the main processes of distraction osteogenesis from a continuum perspective, considering as state variables the population of cells and tissue distributions. Results of the continuum and lattice-based approaches are similar with respect to the global evolution of the different cells but rather different in terms of the type of ossification process. Differences in the size of the soft interzone in the gap have also been found. In addition, the discrete-continuum formulation allows including a more realistic approach of the migration/proliferation process with a discrete random walk model instead of the Fick''s law used in continuum approaches. Also, blood vessel growth can be simulated explicitly in this model with the inclusion of the endothelial cells. Further study is needed to provide additional insights to understand coupled phenomena at different scales in the cell–tissue interactions. However this work provides a first preliminary step for improving multiscale models. [Copyright &y& Elsevier] |
| Copyright of Journal of Biomechanics is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 83164321 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: A lattice-based approach to model distraction osteogenesis – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Reina-Romo%2C+E%2E%22">Reina-Romo, E.</searchLink><relatesTo>1</relatesTo><i> erreina@us.es</i><br /><searchLink fieldCode="AR" term="%22Gómez-Benito%2C+M%2EJ%2E%22">Gómez-Benito, M.J.</searchLink><relatesTo>2</relatesTo><i> gomezmj@unizar.es</i><br /><searchLink fieldCode="AR" term="%22Domínguez%2C+J%2E%22">Domínguez, J.</searchLink><relatesTo>1</relatesTo><i> jaime@us.es</i><br /><searchLink fieldCode="AR" term="%22García-Aznar%2C+J%2EM%2E%22">García-Aznar, J.M.</searchLink><relatesTo>2</relatesTo><i> jmgaraz@unizar.es</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Journal+of+Biomechanics%22">Journal of Biomechanics</searchLink>. Nov2012, Vol. 45 Issue 16, p2736-2742. 7p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Bone+growth%22">Bone growth</searchLink><br /><searchLink fieldCode="DE" term="%22Blood-vessel+development%22">Blood-vessel development</searchLink><br /><searchLink fieldCode="DE" term="%22Endothelial+cells%22">Endothelial cells</searchLink><br /><searchLink fieldCode="DE" term="%22Ossification%22">Ossification</searchLink><br /><searchLink fieldCode="DE" term="%22Mathematical+continuum%22">Mathematical continuum</searchLink><br /><searchLink fieldCode="DE" term="%22Fick's+laws+of+diffusion%22">Fick's laws of diffusion</searchLink><br /><searchLink fieldCode="DE" term="%22Random+walks%22">Random walks</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Abstract: Distraction osteogenesis is a well-known technique in which new bone tissue is created when a distraction displacement is applied through an external frame. This orthopedic process is nowadays focus of intense research, both experimentally and numerically, as there are still many aspects not well understood. The aim of this study is to simulate bone distraction by means of a combined discrete-continuum approach based on a lattice formulation. Existing computational models simulate the main processes of distraction osteogenesis from a continuum perspective, considering as state variables the population of cells and tissue distributions. Results of the continuum and lattice-based approaches are similar with respect to the global evolution of the different cells but rather different in terms of the type of ossification process. Differences in the size of the soft interzone in the gap have also been found. In addition, the discrete-continuum formulation allows including a more realistic approach of the migration/proliferation process with a discrete random walk model instead of the Fick''s law used in continuum approaches. Also, blood vessel growth can be simulated explicitly in this model with the inclusion of the endothelial cells. Further study is needed to provide additional insights to understand coupled phenomena at different scales in the cell–tissue interactions. However this work provides a first preliminary step for improving multiscale models. [Copyright &y& Elsevier] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Journal of Biomechanics is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.jbiomech.2012.09.004 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 7 StartPage: 2736 Subjects: – SubjectFull: Bone growth Type: general – SubjectFull: Blood-vessel development Type: general – SubjectFull: Endothelial cells Type: general – SubjectFull: Ossification Type: general – SubjectFull: Mathematical continuum Type: general – SubjectFull: Fick's laws of diffusion Type: general – SubjectFull: Random walks Type: general Titles: – TitleFull: A lattice-based approach to model distraction osteogenesis Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Reina-Romo, E. – PersonEntity: Name: NameFull: Gómez-Benito, M.J. – PersonEntity: Name: NameFull: Domínguez, J. – PersonEntity: Name: NameFull: García-Aznar, J.M. IsPartOfRelationships: – BibEntity: Dates: – D: 15 M: 11 Text: Nov2012 Type: published Y: 2012 Identifiers: – Type: issn-print Value: 00219290 Numbering: – Type: volume Value: 45 – Type: issue Value: 16 Titles: – TitleFull: Journal of Biomechanics Type: main |
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