Bibliographic Details
| Title: |
Hookerolides A–D, the first naturally occurring C17-pseudoguaianolides from Inula hookeri |
| Authors: |
Cheng, Xiang-Rong1,2, Ren, Jie1, Wang, Chun-Hui1, Guan, Bin1, Qin, Jiang-Jiang1, Yan, Shi-Kai1, Jin, Hui-Zi1 kimhz@sjtu.edu.cn, Zhang, Wei-Dong1,3 wdzhangy@hotmail.com |
| Source: |
Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Apr2013, Vol. 54 Issue 15, p1943-1946. 4p. |
| Subjects: |
Carbon isotopes, Pseudoguaianolides, Chemical structure, Nuclear magnetic resonance spectroscopy, Cell-mediated cytotoxicity, Anti-inflammatory agents |
| Abstract: |
Abstract: Four unprecedented C17-pseudoguaianolides with extended side chains, hookerolides A–D (1–4), were isolated from the whole plants of Inula hookeri. Their structures and absolute configurations were elucidated by a combination of NMR spectroscopy, CD spectrum, and the modified Mosher method. The in vitro bioactivity evaluation suggested that 1–4 possessed moderate to weak anti-inflammatory and cytotoxic properties. [Copyright &y& Elsevier] |
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| Database: |
Engineering Source |
