Gender-Dependence of Bone Structure and Properties in Adult Osteogenesis Imperfecta Murine Model.

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Bibliographic Details
Title:	Gender-Dependence of Bone Structure and Properties in Adult Osteogenesis Imperfecta Murine Model.
Authors:	Yao, Xiaomei¹, Carleton, Stephanie², Kettle, Arin², Melander, Jennifer¹, Phillips, Charlotte² PhillipsCL@missouri.edu, Wang, Yong¹ Wangyo@umkc.edu
Source:	Annals of Biomedical Engineering. Jun2013, Vol. 41 Issue 6, p1139-1149. 11p.
Subjects:	Osteogenesis imperfecta, Sex factors in disease, Laboratory mice, Bones, Tibia, Computed tomography, Raman spectroscopy, Anatomy
Abstract:	Osteogenesis imperfecta (OI) is a dominant skeletal disorder characterized by bone fragility and deformities. Though the oim mouse model has been the most widely studied of the OI models, it has only recently been suggested to exhibit gender-dependent differences in bone mineralization. To characterize the impact of gender on the morphometry/ultra-structure, mechanical properties, and biochemical composition of oim bone on the congenic C57BL/J6 background, 4-month-old oim/ oim, +/ oim, and wild-type ( wt) female and male tibiae were evaluated using micro-computed tomography, three-point bending, and Raman spectroscopy. Dramatic gender differences were evident in both cortical and trabecular bone morphological and geometric parameters. Male mice had inherently more bone and increased moment of inertia than genotype-matched female counterparts with corresponding increases in bone biomechanical strength. The primary influence of gender was structure/geometry in bone growth and mechanical properties, whereas the mineral/matrix composition and hydroxyproline content of bone were influenced primarily by the oim collagen mutation. This study provides evidence of the importance of gender in the evaluation and interpretation of potential therapeutic strategies when using mouse models of OI. [ABSTRACT FROM AUTHOR]
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Database:	Engineering Source

Description
Abstract:	Osteogenesis imperfecta (OI) is a dominant skeletal disorder characterized by bone fragility and deformities. Though the oim mouse model has been the most widely studied of the OI models, it has only recently been suggested to exhibit gender-dependent differences in bone mineralization. To characterize the impact of gender on the morphometry/ultra-structure, mechanical properties, and biochemical composition of oim bone on the congenic C57BL/J6 background, 4-month-old oim/ oim, +/ oim, and wild-type ( wt) female and male tibiae were evaluated using micro-computed tomography, three-point bending, and Raman spectroscopy. Dramatic gender differences were evident in both cortical and trabecular bone morphological and geometric parameters. Male mice had inherently more bone and increased moment of inertia than genotype-matched female counterparts with corresponding increases in bone biomechanical strength. The primary influence of gender was structure/geometry in bone growth and mechanical properties, whereas the mineral/matrix composition and hydroxyproline content of bone were influenced primarily by the oim collagen mutation. This study provides evidence of the importance of gender in the evaluation and interpretation of potential therapeutic strategies when using mouse models of OI. [ABSTRACT FROM AUTHOR]
ISSN:	00906964
DOI:	10.1007/s10439-013-0793-7