Gender-Dependence of Bone Structure and Properties in Adult Osteogenesis Imperfecta Murine Model.
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| Title: | Gender-Dependence of Bone Structure and Properties in Adult Osteogenesis Imperfecta Murine Model. |
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| Authors: | Yao, Xiaomei1, Carleton, Stephanie2, Kettle, Arin2, Melander, Jennifer1, Phillips, Charlotte2 PhillipsCL@missouri.edu, Wang, Yong1 Wangyo@umkc.edu |
| Source: | Annals of Biomedical Engineering. Jun2013, Vol. 41 Issue 6, p1139-1149. 11p. |
| Subjects: | Osteogenesis imperfecta, Sex factors in disease, Laboratory mice, Bones, Tibia, Computed tomography, Raman spectroscopy, Anatomy |
| Abstract: | Osteogenesis imperfecta (OI) is a dominant skeletal disorder characterized by bone fragility and deformities. Though the oim mouse model has been the most widely studied of the OI models, it has only recently been suggested to exhibit gender-dependent differences in bone mineralization. To characterize the impact of gender on the morphometry/ultra-structure, mechanical properties, and biochemical composition of oim bone on the congenic C57BL/J6 background, 4-month-old oim/ oim, +/ oim, and wild-type ( wt) female and male tibiae were evaluated using micro-computed tomography, three-point bending, and Raman spectroscopy. Dramatic gender differences were evident in both cortical and trabecular bone morphological and geometric parameters. Male mice had inherently more bone and increased moment of inertia than genotype-matched female counterparts with corresponding increases in bone biomechanical strength. The primary influence of gender was structure/geometry in bone growth and mechanical properties, whereas the mineral/matrix composition and hydroxyproline content of bone were influenced primarily by the oim collagen mutation. This study provides evidence of the importance of gender in the evaluation and interpretation of potential therapeutic strategies when using mouse models of OI. [ABSTRACT FROM AUTHOR] |
| Copyright of Annals of Biomedical Engineering is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Header | DbId: egs DbLabel: Engineering Source An: 87336680 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Gender-Dependence of Bone Structure and Properties in Adult Osteogenesis Imperfecta Murine Model. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Yao%2C+Xiaomei%22">Yao, Xiaomei</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Carleton%2C+Stephanie%22">Carleton, Stephanie</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Kettle%2C+Arin%22">Kettle, Arin</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Melander%2C+Jennifer%22">Melander, Jennifer</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Phillips%2C+Charlotte%22">Phillips, Charlotte</searchLink><relatesTo>2</relatesTo><i> PhillipsCL@missouri.edu</i><br /><searchLink fieldCode="AR" term="%22Wang%2C+Yong%22">Wang, Yong</searchLink><relatesTo>1</relatesTo><i> Wangyo@umkc.edu</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Annals+of+Biomedical+Engineering%22">Annals of Biomedical Engineering</searchLink>. Jun2013, Vol. 41 Issue 6, p1139-1149. 11p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Osteogenesis+imperfecta%22">Osteogenesis imperfecta</searchLink><br /><searchLink fieldCode="DE" term="%22Sex+factors+in+disease%22">Sex factors in disease</searchLink><br /><searchLink fieldCode="DE" term="%22Laboratory+mice%22">Laboratory mice</searchLink><br /><searchLink fieldCode="DE" term="%22Bones%22">Bones</searchLink><br /><searchLink fieldCode="DE" term="%22Tibia%22">Tibia</searchLink><br /><searchLink fieldCode="DE" term="%22Computed+tomography%22">Computed tomography</searchLink><br /><searchLink fieldCode="DE" term="%22Raman+spectroscopy%22">Raman spectroscopy</searchLink><br /><searchLink fieldCode="DE" term="%22Anatomy%22">Anatomy</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Osteogenesis imperfecta (OI) is a dominant skeletal disorder characterized by bone fragility and deformities. Though the oim mouse model has been the most widely studied of the OI models, it has only recently been suggested to exhibit gender-dependent differences in bone mineralization. To characterize the impact of gender on the morphometry/ultra-structure, mechanical properties, and biochemical composition of oim bone on the congenic C57BL/J6 background, 4-month-old oim/ oim, +/ oim, and wild-type ( wt) female and male tibiae were evaluated using micro-computed tomography, three-point bending, and Raman spectroscopy. Dramatic gender differences were evident in both cortical and trabecular bone morphological and geometric parameters. Male mice had inherently more bone and increased moment of inertia than genotype-matched female counterparts with corresponding increases in bone biomechanical strength. The primary influence of gender was structure/geometry in bone growth and mechanical properties, whereas the mineral/matrix composition and hydroxyproline content of bone were influenced primarily by the oim collagen mutation. This study provides evidence of the importance of gender in the evaluation and interpretation of potential therapeutic strategies when using mouse models of OI. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Annals of Biomedical Engineering is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10439-013-0793-7 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 1139 Subjects: – SubjectFull: Osteogenesis imperfecta Type: general – SubjectFull: Sex factors in disease Type: general – SubjectFull: Laboratory mice Type: general – SubjectFull: Bones Type: general – SubjectFull: Tibia Type: general – SubjectFull: Computed tomography Type: general – SubjectFull: Raman spectroscopy Type: general – SubjectFull: Anatomy Type: general Titles: – TitleFull: Gender-Dependence of Bone Structure and Properties in Adult Osteogenesis Imperfecta Murine Model. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Yao, Xiaomei – PersonEntity: Name: NameFull: Carleton, Stephanie – PersonEntity: Name: NameFull: Kettle, Arin – PersonEntity: Name: NameFull: Melander, Jennifer – PersonEntity: Name: NameFull: Phillips, Charlotte – PersonEntity: Name: NameFull: Wang, Yong IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 06 Text: Jun2013 Type: published Y: 2013 Identifiers: – Type: issn-print Value: 00906964 Numbering: – Type: volume Value: 41 – Type: issue Value: 6 Titles: – TitleFull: Annals of Biomedical Engineering Type: main |
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