Three-component synthesis of poly-substituted tetrahydroindoles through p-TsOH promoted alkoxylation.
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| Title: | Three-component synthesis of poly-substituted tetrahydroindoles through p-TsOH promoted alkoxylation. |
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| Authors: | Shi, Qing-Qing1, Fu, Li-Ping1, Shi, Yu1, Ding, Hua-Qin1, Luo, Jing-Hua1, Jiang, Bo1 jiangchem@jsnu.edu.cn, Tu, Shu-Jiang1 laotu@jsnu.edu.cn |
| Source: | Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Jun2013, Vol. 54 Issue 24, p3176-3179. 4p. |
| Subjects: | Substitution reactions, Indole compounds, Organic synthesis, Alkoxylation, Chemical derivatives, Chemical reactions |
| Abstract: | Abstract: Concise and efficient three-component domino reactions to highly substituted tetrahydroindole derivatives promoted by p-TsOH have been developed under microwave irradiation condition. The direct C3-alkoxylation of indole framework was achieved in a one-pot operation. The reaction proceeds at fast rates and can be finished within 30min, which makes workup convenient to give good chemical yields. [Copyright &y& Elsevier] |
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| Database: | Engineering Source |
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