View in EDS

Interaction between PAMAM-NH2 G4 dendrimer and paracetamol in aqueous solution.

Saved in:
Bibliographic Details
Title: Interaction between PAMAM-NH2 G4 dendrimer and paracetamol in aqueous solution.
Authors: Buczkowski, Adam1 buczkowski_adam@tlen.pl, Urbaniak, Pawel2, Palecz, Bartlomiej1 paleczb@uni.lodz.pl
Source: Journal of Molecular Liquids. Oct2013, Vol. 186, p70-75. 6p.
Subjects: Dendrimers, Acetaminophen, Aqueous solutions, Chemical equilibrium, Drug solubility, Exothermic reactions, Molecular models
Abstract: Interactions between PAMAM-NH2 G4 dendrimer and paracetamol in aqueous solutions were examined by UV spectroscopy, equilibrium dialysis, 1H NMR spectroscopy and calorimetric techniques. The results of equilibrium dialysis show that PAMAM-NH2 G4 dendrimer can combine 18 paracetamol molecules with equilibrium constant K =280±40. Using the method of calorimetric titration (ITC), it has been found that the paracetamol addition to dendrimer is an exothermic process. Based on the model of two active sites in a dendrimer molecule, the results of equilibrium dialyses were described and it was calculated that a molecule of dendrimer has about three sites strongly combining paracetamol (K 1 =2100±670) and about 15 sites that weakly combine the drug (K 2 =130±30). The measurements of paracetamol solubility in aqueous solutions of PAMAM-NH2 G4 dendrimer confirm the paracetamol addition to this dendrimer. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Molecular Liquids is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
Description
Abstract:Interactions between PAMAM-NH2 G4 dendrimer and paracetamol in aqueous solutions were examined by UV spectroscopy, equilibrium dialysis, 1H NMR spectroscopy and calorimetric techniques. The results of equilibrium dialysis show that PAMAM-NH2 G4 dendrimer can combine 18 paracetamol molecules with equilibrium constant K =280±40. Using the method of calorimetric titration (ITC), it has been found that the paracetamol addition to dendrimer is an exothermic process. Based on the model of two active sites in a dendrimer molecule, the results of equilibrium dialyses were described and it was calculated that a molecule of dendrimer has about three sites strongly combining paracetamol (K 1 =2100±670) and about 15 sites that weakly combine the drug (K 2 =130±30). The measurements of paracetamol solubility in aqueous solutions of PAMAM-NH2 G4 dendrimer confirm the paracetamol addition to this dendrimer. [ABSTRACT FROM AUTHOR]
ISSN:01677322
DOI:10.1016/j.molliq.2013.05.021