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Efficacy of intra-tendinous injection of platelet-rich plasma in treating tendinosis: comprehensive assessment of a rat model.

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Title: Efficacy of intra-tendinous injection of platelet-rich plasma in treating tendinosis: comprehensive assessment of a rat model.
Authors: Dallaudière, Benjamin benjamin.dallaudiere@gmail.com, Lempicki, Marta, Pesquer, Lionel1, Louedec, Liliane2, Preux, Pierre3, Meyer, Philippe1, Hummel, Vincent4, Larbi, Ahmed4, Deschamps, Lydia5, Journe, Clement6, Hess, Agathe, Silvestre, Alain1, Sargos, Paul4, Loriaut, Philippe7, Boyer, Patrick7, Schouman-Claeys, Elisabeth, Michel, Jean2, Serfaty, Jean
Source: European Radiology. Oct2013, Vol. 23 Issue 10, p2830-2837. 8p. 2 Color Photographs, 2 Black and White Photographs, 2 Charts.
Subjects: Tendinosis, Platelet-rich plasma, Laboratory rats, Achilles tendinitis, Collagenases, Medical imaging systems
Abstract: Objectives: To assess the potential of intra-tendinous injection of platelet rich plasma (PRP) to treat tendinosis (T+) in a rat model of patellar and Achilles T+, and evaluate its local toxicity. Methods: Thirty rats (120 patellar and Achilles tendons) were used. We induced T+ into 80 tendons (patellar = 40, Achilles = 40) by injecting collagenase at day 0 under ultrasound (US) guidance. Clinical examination and US at day 3, followed by US-guided intra-tendinous injection of either PRP (PRPT+, n = 40) or physiological serum (ST+, n = 40, control). Follow-up was at days 6, 13, 18 and 25 using clinical, US and histological evaluation. To study PRP toxicity, we injected PRP into 40 normal tendons (PRPT-) and compared with 40 untreated normal tendons (T-). Results: All PRPT+ showed better joint mobilisation compared with ST+ at day 6 ( P = 0.005), day 13 ( P = 0.02), day 18 ( P = 0.003) and day 25 ( P = 0.01). Similar results were found regarding US and histology, with smaller collagen fibre diameters (day 6, P = 0.003, day 25, P ≤ 0.004), less disorganisation and fewer neovessels (day 6, P = 0.003, day 25, P = 0.0003) in PRPT+ compared with ST+. Comparison between PRPT- and T- showed no PRP toxicity ( P = 0.18). Conclusions: Our study suggests that mono-injection of PRP in T+ improves tendon healing, with no local toxicity. Key Points: • We assessed the potential of platelet rich plasma (PRP) to treat tendinosis. • We treated patellar and Achilles tendinosis in a rat model. • We evaluated clinical, imaging and histological data. • Intra-tendinous PRP injection could be useful in the treatment of tendinosis. [ABSTRACT FROM AUTHOR]
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Abstract:Objectives: To assess the potential of intra-tendinous injection of platelet rich plasma (PRP) to treat tendinosis (T+) in a rat model of patellar and Achilles T+, and evaluate its local toxicity. Methods: Thirty rats (120 patellar and Achilles tendons) were used. We induced T+ into 80 tendons (patellar = 40, Achilles = 40) by injecting collagenase at day 0 under ultrasound (US) guidance. Clinical examination and US at day 3, followed by US-guided intra-tendinous injection of either PRP (PRPT+, n = 40) or physiological serum (ST+, n = 40, control). Follow-up was at days 6, 13, 18 and 25 using clinical, US and histological evaluation. To study PRP toxicity, we injected PRP into 40 normal tendons (PRPT-) and compared with 40 untreated normal tendons (T-). Results: All PRPT+ showed better joint mobilisation compared with ST+ at day 6 ( P = 0.005), day 13 ( P = 0.02), day 18 ( P = 0.003) and day 25 ( P = 0.01). Similar results were found regarding US and histology, with smaller collagen fibre diameters (day 6, P = 0.003, day 25, P ≤ 0.004), less disorganisation and fewer neovessels (day 6, P = 0.003, day 25, P = 0.0003) in PRPT+ compared with ST+. Comparison between PRPT- and T- showed no PRP toxicity ( P = 0.18). Conclusions: Our study suggests that mono-injection of PRP in T+ improves tendon healing, with no local toxicity. Key Points: • We assessed the potential of platelet rich plasma (PRP) to treat tendinosis. • We treated patellar and Achilles tendinosis in a rat model. • We evaluated clinical, imaging and histological data. • Intra-tendinous PRP injection could be useful in the treatment of tendinosis. [ABSTRACT FROM AUTHOR]
ISSN:09387994
DOI:10.1007/s00330-013-2926-7