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Efficacy of intra-tendinous injection of platelet-rich plasma in treating tendinosis: comprehensive assessment of a rat model.

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Title: Efficacy of intra-tendinous injection of platelet-rich plasma in treating tendinosis: comprehensive assessment of a rat model.
Authors: Dallaudière, Benjamin benjamin.dallaudiere@gmail.com, Lempicki, Marta, Pesquer, Lionel1, Louedec, Liliane2, Preux, Pierre3, Meyer, Philippe1, Hummel, Vincent4, Larbi, Ahmed4, Deschamps, Lydia5, Journe, Clement6, Hess, Agathe, Silvestre, Alain1, Sargos, Paul4, Loriaut, Philippe7, Boyer, Patrick7, Schouman-Claeys, Elisabeth, Michel, Jean2, Serfaty, Jean
Source: European Radiology. Oct2013, Vol. 23 Issue 10, p2830-2837. 8p. 2 Color Photographs, 2 Black and White Photographs, 2 Charts.
Subjects: Tendinosis, Platelet-rich plasma, Laboratory rats, Achilles tendinitis, Collagenases, Medical imaging systems
Abstract: Objectives: To assess the potential of intra-tendinous injection of platelet rich plasma (PRP) to treat tendinosis (T+) in a rat model of patellar and Achilles T+, and evaluate its local toxicity. Methods: Thirty rats (120 patellar and Achilles tendons) were used. We induced T+ into 80 tendons (patellar = 40, Achilles = 40) by injecting collagenase at day 0 under ultrasound (US) guidance. Clinical examination and US at day 3, followed by US-guided intra-tendinous injection of either PRP (PRPT+, n = 40) or physiological serum (ST+, n = 40, control). Follow-up was at days 6, 13, 18 and 25 using clinical, US and histological evaluation. To study PRP toxicity, we injected PRP into 40 normal tendons (PRPT-) and compared with 40 untreated normal tendons (T-). Results: All PRPT+ showed better joint mobilisation compared with ST+ at day 6 ( P = 0.005), day 13 ( P = 0.02), day 18 ( P = 0.003) and day 25 ( P = 0.01). Similar results were found regarding US and histology, with smaller collagen fibre diameters (day 6, P = 0.003, day 25, P ≤ 0.004), less disorganisation and fewer neovessels (day 6, P = 0.003, day 25, P = 0.0003) in PRPT+ compared with ST+. Comparison between PRPT- and T- showed no PRP toxicity ( P = 0.18). Conclusions: Our study suggests that mono-injection of PRP in T+ improves tendon healing, with no local toxicity. Key Points: • We assessed the potential of platelet rich plasma (PRP) to treat tendinosis. • We treated patellar and Achilles tendinosis in a rat model. • We evaluated clinical, imaging and histological data. • Intra-tendinous PRP injection could be useful in the treatment of tendinosis. [ABSTRACT FROM AUTHOR]
Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Efficacy of intra-tendinous injection of platelet-rich plasma in treating tendinosis: comprehensive assessment of a rat model.
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  Data: <searchLink fieldCode="AR" term="%22Dallaudière%2C+Benjamin%22">Dallaudière, Benjamin</searchLink><i> benjamin.dallaudiere@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Lempicki%2C+Marta%22">Lempicki, Marta</searchLink><br /><searchLink fieldCode="AR" term="%22Pesquer%2C+Lionel%22">Pesquer, Lionel</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Louedec%2C+Liliane%22">Louedec, Liliane</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Preux%2C+Pierre%22">Preux, Pierre</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Meyer%2C+Philippe%22">Meyer, Philippe</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Hummel%2C+Vincent%22">Hummel, Vincent</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Larbi%2C+Ahmed%22">Larbi, Ahmed</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Deschamps%2C+Lydia%22">Deschamps, Lydia</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Journe%2C+Clement%22">Journe, Clement</searchLink><relatesTo>6</relatesTo><br /><searchLink fieldCode="AR" term="%22Hess%2C+Agathe%22">Hess, Agathe</searchLink><br /><searchLink fieldCode="AR" term="%22Silvestre%2C+Alain%22">Silvestre, Alain</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Sargos%2C+Paul%22">Sargos, Paul</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Loriaut%2C+Philippe%22">Loriaut, Philippe</searchLink><relatesTo>7</relatesTo><br /><searchLink fieldCode="AR" term="%22Boyer%2C+Patrick%22">Boyer, Patrick</searchLink><relatesTo>7</relatesTo><br /><searchLink fieldCode="AR" term="%22Schouman-Claeys%2C+Elisabeth%22">Schouman-Claeys, Elisabeth</searchLink><br /><searchLink fieldCode="AR" term="%22Michel%2C+Jean%22">Michel, Jean</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Serfaty%2C+Jean%22">Serfaty, Jean</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22European+Radiology%22">European Radiology</searchLink>. Oct2013, Vol. 23 Issue 10, p2830-2837. 8p. 2 Color Photographs, 2 Black and White Photographs, 2 Charts.
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  Data: <searchLink fieldCode="DE" term="%22Tendinosis%22">Tendinosis</searchLink><br /><searchLink fieldCode="DE" term="%22Platelet-rich+plasma%22">Platelet-rich plasma</searchLink><br /><searchLink fieldCode="DE" term="%22Laboratory+rats%22">Laboratory rats</searchLink><br /><searchLink fieldCode="DE" term="%22Achilles+tendinitis%22">Achilles tendinitis</searchLink><br /><searchLink fieldCode="DE" term="%22Collagenases%22">Collagenases</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+imaging+systems%22">Medical imaging systems</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objectives: To assess the potential of intra-tendinous injection of platelet rich plasma (PRP) to treat tendinosis (T+) in a rat model of patellar and Achilles T+, and evaluate its local toxicity. Methods: Thirty rats (120 patellar and Achilles tendons) were used. We induced T+ into 80 tendons (patellar = 40, Achilles = 40) by injecting collagenase at day 0 under ultrasound (US) guidance. Clinical examination and US at day 3, followed by US-guided intra-tendinous injection of either PRP (PRPT+, n = 40) or physiological serum (ST+, n = 40, control). Follow-up was at days 6, 13, 18 and 25 using clinical, US and histological evaluation. To study PRP toxicity, we injected PRP into 40 normal tendons (PRPT-) and compared with 40 untreated normal tendons (T-). Results: All PRPT+ showed better joint mobilisation compared with ST+ at day 6 ( P = 0.005), day 13 ( P = 0.02), day 18 ( P = 0.003) and day 25 ( P = 0.01). Similar results were found regarding US and histology, with smaller collagen fibre diameters (day 6, P = 0.003, day 25, P ≤ 0.004), less disorganisation and fewer neovessels (day 6, P = 0.003, day 25, P = 0.0003) in PRPT+ compared with ST+. Comparison between PRPT- and T- showed no PRP toxicity ( P = 0.18). Conclusions: Our study suggests that mono-injection of PRP in T+ improves tendon healing, with no local toxicity. Key Points: • We assessed the potential of platelet rich plasma (PRP) to treat tendinosis. • We treated patellar and Achilles tendinosis in a rat model. • We evaluated clinical, imaging and histological data. • Intra-tendinous PRP injection could be useful in the treatment of tendinosis. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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