Effect of Mechanical Strain on Solute Diffusion in Human TMJ Discs: An Electrical Conductivity Study.

Saved in:

Bibliographic Details
Title:	Effect of Mechanical Strain on Solute Diffusion in Human TMJ Discs: An Electrical Conductivity Study.
Authors:	Wright, Gregory¹, Kuo, Jonathan¹, Shi, Changcheng¹, Bacro, Thierry², Slate, Elizabeth³, Yao, Hai haiyao@clemson.edu
Source:	Annals of Biomedical Engineering. Nov2013, Vol. 41 Issue 11, p2349-2357. 9p. 1 Diagram, 1 Chart, 3 Graphs.
Subjects:	Physiologic strain, Biomechanics, Electric conductivity, Pathological physiology, Diffusion
Abstract:	This study investigated the effect of mechanical strain on solute diffusion in human TMJ discs (mean cadaver age 77.8) using the electrical conductivity method. The electrical conductivity, as well as small ion diffusivity, of male and female TMJ discs was determined under three compressive strains. In the male group, the average disc electrical conductivity (mean ± SD) at 0% strain was 5.14 ± 0.97 mS/cm, decreased to 4.50 ± 0.91 mS/cm (−12.3%) at 10% strain, and 3.93 ± 0.81 mS/cm (−23.5%) at 20% compressive strain. Correspondingly, the average disc relative ion diffusivity at 0% strain was 0.44 ± 0.08, decreased to 0.40 ± 0.08 (−8.9%) at 10% strain, and 0.36 ± 0.08 (−16.7%) at 20% compressive strain. In the female group, the average disc electrical conductivity at 0% strain was 5.84 ± 0.59 mS/cm, decreased to 5.01 ± 0.50 mS/cm (−14.2%) at 10% strain, and 4.33 ± 0.46 mS/cm (−25.8%) at 20% compressive strain. Correspondingly, the average disc relative ion diffusivity at 0% strain was 0.49 ± 0.05, decreased to 0.43 ± 0.04 (−11.3%) at 10% strain, and 0.39 ± 0.04 (−19.9%) at 20% compressive strain. The results indicated that mechanical strain significantly impeded solute diffusion through the disc. This mechanical strain effect was larger in the female than in the male human TMJ disc. This study may provide new insights into TMJ pathophysiology. [ABSTRACT FROM AUTHOR]
	Copyright of Annals of Biomedical Engineering is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database:	Engineering Source

Description
Abstract:	This study investigated the effect of mechanical strain on solute diffusion in human TMJ discs (mean cadaver age 77.8) using the electrical conductivity method. The electrical conductivity, as well as small ion diffusivity, of male and female TMJ discs was determined under three compressive strains. In the male group, the average disc electrical conductivity (mean ± SD) at 0% strain was 5.14 ± 0.97 mS/cm, decreased to 4.50 ± 0.91 mS/cm (−12.3%) at 10% strain, and 3.93 ± 0.81 mS/cm (−23.5%) at 20% compressive strain. Correspondingly, the average disc relative ion diffusivity at 0% strain was 0.44 ± 0.08, decreased to 0.40 ± 0.08 (−8.9%) at 10% strain, and 0.36 ± 0.08 (−16.7%) at 20% compressive strain. In the female group, the average disc electrical conductivity at 0% strain was 5.84 ± 0.59 mS/cm, decreased to 5.01 ± 0.50 mS/cm (−14.2%) at 10% strain, and 4.33 ± 0.46 mS/cm (−25.8%) at 20% compressive strain. Correspondingly, the average disc relative ion diffusivity at 0% strain was 0.49 ± 0.05, decreased to 0.43 ± 0.04 (−11.3%) at 10% strain, and 0.39 ± 0.04 (−19.9%) at 20% compressive strain. The results indicated that mechanical strain significantly impeded solute diffusion through the disc. This mechanical strain effect was larger in the female than in the male human TMJ disc. This study may provide new insights into TMJ pathophysiology. [ABSTRACT FROM AUTHOR]
ISSN:	00906964
DOI:	10.1007/s10439-013-0840-4