Effect of Mechanical Strain on Solute Diffusion in Human TMJ Discs: An Electrical Conductivity Study.
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| Title: | Effect of Mechanical Strain on Solute Diffusion in Human TMJ Discs: An Electrical Conductivity Study. |
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| Authors: | Wright, Gregory1, Kuo, Jonathan1, Shi, Changcheng1, Bacro, Thierry2, Slate, Elizabeth3, Yao, Hai haiyao@clemson.edu |
| Source: | Annals of Biomedical Engineering. Nov2013, Vol. 41 Issue 11, p2349-2357. 9p. 1 Diagram, 1 Chart, 3 Graphs. |
| Subjects: | Physiologic strain, Biomechanics, Electric conductivity, Pathological physiology, Diffusion |
| Abstract: | This study investigated the effect of mechanical strain on solute diffusion in human TMJ discs (mean cadaver age 77.8) using the electrical conductivity method. The electrical conductivity, as well as small ion diffusivity, of male and female TMJ discs was determined under three compressive strains. In the male group, the average disc electrical conductivity (mean ± SD) at 0% strain was 5.14 ± 0.97 mS/cm, decreased to 4.50 ± 0.91 mS/cm (−12.3%) at 10% strain, and 3.93 ± 0.81 mS/cm (−23.5%) at 20% compressive strain. Correspondingly, the average disc relative ion diffusivity at 0% strain was 0.44 ± 0.08, decreased to 0.40 ± 0.08 (−8.9%) at 10% strain, and 0.36 ± 0.08 (−16.7%) at 20% compressive strain. In the female group, the average disc electrical conductivity at 0% strain was 5.84 ± 0.59 mS/cm, decreased to 5.01 ± 0.50 mS/cm (−14.2%) at 10% strain, and 4.33 ± 0.46 mS/cm (−25.8%) at 20% compressive strain. Correspondingly, the average disc relative ion diffusivity at 0% strain was 0.49 ± 0.05, decreased to 0.43 ± 0.04 (−11.3%) at 10% strain, and 0.39 ± 0.04 (−19.9%) at 20% compressive strain. The results indicated that mechanical strain significantly impeded solute diffusion through the disc. This mechanical strain effect was larger in the female than in the male human TMJ disc. This study may provide new insights into TMJ pathophysiology. [ABSTRACT FROM AUTHOR] |
| Copyright of Annals of Biomedical Engineering is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Items | – Name: Title Label: Title Group: Ti Data: Effect of Mechanical Strain on Solute Diffusion in Human TMJ Discs: An Electrical Conductivity Study. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Wright%2C+Gregory%22">Wright, Gregory</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Kuo%2C+Jonathan%22">Kuo, Jonathan</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Shi%2C+Changcheng%22">Shi, Changcheng</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Bacro%2C+Thierry%22">Bacro, Thierry</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Slate%2C+Elizabeth%22">Slate, Elizabeth</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Yao%2C+Hai%22">Yao, Hai</searchLink><i> haiyao@clemson.edu</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Annals+of+Biomedical+Engineering%22">Annals of Biomedical Engineering</searchLink>. Nov2013, Vol. 41 Issue 11, p2349-2357. 9p. 1 Diagram, 1 Chart, 3 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Physiologic+strain%22">Physiologic strain</searchLink><br /><searchLink fieldCode="DE" term="%22Biomechanics%22">Biomechanics</searchLink><br /><searchLink fieldCode="DE" term="%22Electric+conductivity%22">Electric conductivity</searchLink><br /><searchLink fieldCode="DE" term="%22Pathological+physiology%22">Pathological physiology</searchLink><br /><searchLink fieldCode="DE" term="%22Diffusion%22">Diffusion</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: This study investigated the effect of mechanical strain on solute diffusion in human TMJ discs (mean cadaver age 77.8) using the electrical conductivity method. The electrical conductivity, as well as small ion diffusivity, of male and female TMJ discs was determined under three compressive strains. In the male group, the average disc electrical conductivity (mean ± SD) at 0% strain was 5.14 ± 0.97 mS/cm, decreased to 4.50 ± 0.91 mS/cm (−12.3%) at 10% strain, and 3.93 ± 0.81 mS/cm (−23.5%) at 20% compressive strain. Correspondingly, the average disc relative ion diffusivity at 0% strain was 0.44 ± 0.08, decreased to 0.40 ± 0.08 (−8.9%) at 10% strain, and 0.36 ± 0.08 (−16.7%) at 20% compressive strain. In the female group, the average disc electrical conductivity at 0% strain was 5.84 ± 0.59 mS/cm, decreased to 5.01 ± 0.50 mS/cm (−14.2%) at 10% strain, and 4.33 ± 0.46 mS/cm (−25.8%) at 20% compressive strain. Correspondingly, the average disc relative ion diffusivity at 0% strain was 0.49 ± 0.05, decreased to 0.43 ± 0.04 (−11.3%) at 10% strain, and 0.39 ± 0.04 (−19.9%) at 20% compressive strain. The results indicated that mechanical strain significantly impeded solute diffusion through the disc. This mechanical strain effect was larger in the female than in the male human TMJ disc. This study may provide new insights into TMJ pathophysiology. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Annals of Biomedical Engineering is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10439-013-0840-4 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 2349 Subjects: – SubjectFull: Physiologic strain Type: general – SubjectFull: Biomechanics Type: general – SubjectFull: Electric conductivity Type: general – SubjectFull: Pathological physiology Type: general – SubjectFull: Diffusion Type: general Titles: – TitleFull: Effect of Mechanical Strain on Solute Diffusion in Human TMJ Discs: An Electrical Conductivity Study. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Wright, Gregory – PersonEntity: Name: NameFull: Kuo, Jonathan – PersonEntity: Name: NameFull: Shi, Changcheng – PersonEntity: Name: NameFull: Bacro, Thierry – PersonEntity: Name: NameFull: Slate, Elizabeth – PersonEntity: Name: NameFull: Yao, Hai IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 11 Text: Nov2013 Type: published Y: 2013 Identifiers: – Type: issn-print Value: 00906964 Numbering: – Type: volume Value: 41 – Type: issue Value: 11 Titles: – TitleFull: Annals of Biomedical Engineering Type: main |
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