Bibliographic Details
| Title: |
Analysis of photon count data from single-molecule fluorescence experiments |
| Authors: |
Burzykowski, T.1 tomasz.burzykowski@luc.ac.be, Szubiakowski, J.2 jpszub@matman.uwm.edu.pl, Rydén, T.3 tobias.ryden@matstat.lu.se |
| Source: |
Chemical Physics. Mar2003, Vol. 288 Issue 2/3, p291. 17p. |
| Subjects: |
Molecular theory, Fluorescence spectroscopy |
| Abstract: |
We consider single-molecule fluorescence experiments with data in the form of counts of photons registered over multiple time-intervals. Based on the observation schemes, linking back to works by Dehmelt [Bull. Am. Phys. Soc. 20 (1975) 60] and Cook and Kimble [Phys. Rev. Lett. 54 (1985) 1023], we propose an analytical approach to the data based on the theory of Markov-modulated Poisson processes (MMPP). In particular, we consider maximum-likelihood estimation. The method is illustrated using a real-life dataset. Additionally, the properties of the proposed method are investigated through simulations and compared to two other approaches developed by Yip et al. [J. Phys. Chem. A 102 (1998) 7564] and Molski [Chem. Phys. Lett. 324 (2000) 301]. [Copyright &y& Elsevier] |
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| Database: |
Engineering Source |
