Bibliographic Details
| Title: |
Reversed phase free ion selective radiotracer extraction (RP-FISRE): A new tool to assess the dynamic stabilities of metal (-organic) complexes, for complex half-lives spanning six orders of magnitude. |
| Authors: |
van der Meer, Astrid1 A.J.G.M.vandermeer@tudelft.nl, Breeman, Wouter A.P.2, Wolterbeek, Bert1 |
| Source: |
Applied Radiation & Isotopes. Dec2013, Vol. 82, p28-35. 8p. |
| Subjects: |
Radioactive tracers, Dynamic stability, Metal complexes, Elution (Chromatography), Performance evaluation, Solid phase extraction |
| Abstract: |
Abstract: This paper introduces reversed phase free ion selective radiotracer extraction (RP-FISRE) as a new tool to assess the stability of metal complexes, as illustrated by the assessment of the stability of [177Lu]Lu-DOTA-octreotate. To this end, the TUDelft-developed FISRE, where the released metal is column-retained and the complex eluted, was changed into RP-FISRE, where the complex is column-retained and the released metal is eluted. This change in the approach allows for studies to be performed with high stability complexes. This paper presents RP-FISRE, the strength of the radiotracer approach, and the first-ever k d data on the release of 177Lu from [177Lu]Lu-DOTA-octreotate. [Copyright &y& Elsevier] |
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| Database: |
Engineering Source |
