Synthesis of PHB-based carrier for drug delivery systems with pH-controlled release.

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Bibliographic Details
Title: Synthesis of PHB-based carrier for drug delivery systems with pH-controlled release.
Authors: Michalak, Michał1, Marek, Adam A.2, Zawadiak, Jan2, Kawalec, Michał1, Kurcok, Piotr1 piotr.kurcok@cmpw-pan.edu.pl
Source: European Polymer Journal. Dec2013, Vol. 49 Issue 12, p4149-4156. 8p.
Subjects: Poly-beta-hydroxybutyrate, Fatty acid synthesis, Drug delivery systems, pH effect, Bioconjugates, Amines
Abstract: Highlights: [•] Selective transformation of PHB crotonate into PHB glyoxylate via ozonolysis. [•] Model drug delivery system – conjugate of PHB glyoxylate with primary amine. [•] pH-controlled release of amine from the model conjugate. [Copyright &y& Elsevier]
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Database: Engineering Source
Description
Abstract:Highlights: [•] Selective transformation of PHB crotonate into PHB glyoxylate via ozonolysis. [•] Model drug delivery system – conjugate of PHB glyoxylate with primary amine. [•] pH-controlled release of amine from the model conjugate. [Copyright &y& Elsevier]
ISSN:00143057
DOI:10.1016/j.eurpolymj.2013.09.021