Bibliographic Details
| Title: |
Bioactive eudesmane and germacrane derivatives from Inula wissmanniana Hand.-Mazz. |
| Authors: |
Cheng, Xiang-Rong1,2, Zhang, Shou-De3, Wang, Chun-Hui1, Ren, Jie1, Qin, Jiang-Jiang1, Tang, Xue2, Shen, Yun-Heng4, Yan, Shi-Kai1, Jin, Hui-Zi1 kimhz@sjtu.edu.cn, Zhang, Wei-Dong1,4 wdzhangy@hotmail.com |
| Source: |
Phytochemistry. Dec2013, Vol. 96, p214-222. 9p. |
| Subjects: |
Bioactive compounds, Eudesmanes derivatives, Sesquiterpenes, Inulase, Stereochemistry, Macrophages, Cell-mediated cytotoxicity |
| Abstract: |
Highlights: [•] 12 New and 9 known eudesmanes and germacranes were isolated from the whole plants of I. wissmanniana. [•] Rare 4,5-secoeudesmane, 3,4-secoeudesmane, and eudesman-12,5-olides were elucidated. [•] Unusual germacra-4-en-12,6-olides were reported as well. [•] ECD and X-ray analyses were applied to determine the absolute stereochemistry of new isolates. [•] Some isolates exhibited strong NO inhibition in macrophages and cytotoxicity in tumor cells. [Copyright &y& Elsevier] |
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| Database: |
Engineering Source |
