Bibliographic Details
| Title: |
Antisense oligodeoxynucleotides to NMDA-Ri receptor channel protect cortical neurons from... |
| Authors: |
Wahlestedt, C., Golanov, E. |
| Source: |
Nature. 5/20/1993, Vol. 363 Issue 6426, p260. 4p. 1 Diagram, 8 Graphs. |
| Subjects: |
Nervous system |
| Abstract: |
States that the excitatory amino acid, L-glutamate, acting through its N-methyl-D-aspartate (NMDA) receptor, may contribute to neuronal death following cerebral vascular occlusion. Demonstration that the inhibition of the synthesis of NMDA-R1 by treatment with antisense oligodeoxynucleotides selectively reduces the expression of NMDA receptors; Reduction of the volume of focal ischemic infarction produced by occlusion of the middle cerebral artery in the rat. |
| Database: |
Engineering Source |
