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Antisense oligodeoxynucleotides to NMDA-Ri receptor channel protect cortical neurons from...

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Title: Antisense oligodeoxynucleotides to NMDA-Ri receptor channel protect cortical neurons from...
Authors: Wahlestedt, C., Golanov, E.
Source: Nature. 5/20/1993, Vol. 363 Issue 6426, p260. 4p. 1 Diagram, 8 Graphs.
Subjects: Nervous system
Abstract: States that the excitatory amino acid, L-glutamate, acting through its N-methyl-D-aspartate (NMDA) receptor, may contribute to neuronal death following cerebral vascular occlusion. Demonstration that the inhibition of the synthesis of NMDA-R1 by treatment with antisense oligodeoxynucleotides selectively reduces the expression of NMDA receptors; Reduction of the volume of focal ischemic infarction produced by occlusion of the middle cerebral artery in the rat.
Database: Engineering Source
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  Data: States that the excitatory amino acid, L-glutamate, acting through its N-methyl-D-aspartate (NMDA) receptor, may contribute to neuronal death following cerebral vascular occlusion. Demonstration that the inhibition of the synthesis of NMDA-R1 by treatment with antisense oligodeoxynucleotides selectively reduces the expression of NMDA receptors; Reduction of the volume of focal ischemic infarction produced by occlusion of the middle cerebral artery in the rat.
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        Value: 10.1038/363260a0
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              Text: 5/20/1993
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