Nonhydrolyzable phosphotyrosyl mimetics for the preparation of phosphatase-resistant SH2 domain...
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| Title: | Nonhydrolyzable phosphotyrosyl mimetics for the preparation of phosphatase-resistant SH2 domain... |
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| Authors: | Burke Jr., Terrence R., Smith, Mark S. |
| Source: | Biochemistry. 5/31/94, Vol. 33 Issue 21, p6490. 5p. 6 Graphs. |
| Subjects: | Peptides, Phosphatases |
| Abstract: | Describes the development of Src homology 2 (SH2) inhibitory peptides containing phosphatase-resistant phosphotyrosyl (pTyr) surrogates. SH2 domain inhibitor design; Phosphonopeptide binding; Sensitivity to phosphatases. |
| Database: | Engineering Source |
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