An ex Vivo Human Lung Model for Ultrasound-Guided High-Intensity Focused Ultrasound Therapy Using Lung Flooding.
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| Title: | An ex Vivo Human Lung Model for Ultrasound-Guided High-Intensity Focused Ultrasound Therapy Using Lung Flooding. |
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| Authors: | Wolfram, Frank1 Frank.Wolfram@wkg.srh.de, Reichenbach, Jürgen R.2, Lesser, Thomas G.1 |
| Source: | Ultrasound in Medicine & Biology. Mar2014, Vol. 40 Issue 3, p496-503. 8p. |
| Subjects: | Ultrasonic imaging, Exposure therapy, Lung physiology, Lung cancer diagnosis, Atelectasis, Attenuation coefficients |
| Abstract: | Abstract: The usability of an ex vivo human lung model for ablation of lung cancer tissue with high-intensity focused ultrasound (HIFU) is described. Lung lobes were flooded with saline, with no gas remaining after complete atelectasis. The tumor was delineated sono-morphologically. Speed of sound, tissue density and ultrasound attenuation were measured for flooded lung and different pulmonary cancer tissues. The acoustic impedance of lung cancer tissue (1.6–1.9 mega-Rayleighs) was higher than that of water, as was its attenuation coefficient (0.31–0.44 dB/cm/MHz) compared with that of the flooded lung (0.12 dB/cm/MHz). After application of HIFU, the temperature in centrally located lung cancer surrounded by the flooded lung increased as high as 80°C, which is sufficient for treatment. On the basis of these preliminary results, ultrasound-guided HIFU ablation of lung cancer, by lung flooding with saline, appears feasible and should be explored in future clinical studies. [Copyright &y& Elsevier] |
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| Database: | Engineering Source |
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