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Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha.

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Bibliographic Details
Title:	Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha.
Authors:	Bourguet, William, Ruff, Marc
Source:	Nature. 6/1/1995, Vol. 375 Issue 6530, p377. 6p. 14 Color Photographs, 3 Diagrams.
Subjects:	Ligand binding (Biochemistry), Receptor-ligand complexes, Retinoids
Abstract:	Discusses the study which analyzed the crystal structure of ligand-binding domain (LBD) of human retinoid receptor, RXR-alpha for 9-cis retinoic acid. Dimeric packing of fold of anatiparallel alpha-helical sandwich; Homodimerization of RXR-alpha and LBD; Interaction of 9-cis retinoic acid with transactivation function AF-2; Prototype structure of fold.
Database:	Engineering Source

Description
Abstract:	Discusses the study which analyzed the crystal structure of ligand-binding domain (LBD) of human retinoid receptor, RXR-alpha for 9-cis retinoic acid. Dimeric packing of fold of anatiparallel alpha-helical sandwich; Homodimerization of RXR-alpha and LBD; Interaction of 9-cis retinoic acid with transactivation function AF-2; Prototype structure of fold.
ISSN:	00280836
DOI:	10.1038/375377a0