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Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha.

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Title: Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha.
Authors: Bourguet, William, Ruff, Marc
Source: Nature. 6/1/1995, Vol. 375 Issue 6530, p377. 6p. 14 Color Photographs, 3 Diagrams.
Subjects: Ligand binding (Biochemistry), Receptor-ligand complexes, Retinoids
Abstract: Discusses the study which analyzed the crystal structure of ligand-binding domain (LBD) of human retinoid receptor, RXR-alpha for 9-cis retinoic acid. Dimeric packing of fold of anatiparallel alpha-helical sandwich; Homodimerization of RXR-alpha and LBD; Interaction of 9-cis retinoic acid with transactivation function AF-2; Prototype structure of fold.
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 9507090539
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
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  Group: Ti
  Data: Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha.
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  Data: <searchLink fieldCode="AR" term="%22Bourguet%2C+William%22">Bourguet, William</searchLink><br /><searchLink fieldCode="AR" term="%22Ruff%2C+Marc%22">Ruff, Marc</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Nature%22">Nature</searchLink>. 6/1/1995, Vol. 375 Issue 6530, p377. 6p. 14 Color Photographs, 3 Diagrams.
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  Data: <searchLink fieldCode="DE" term="%22Ligand+binding+%28Biochemistry%29%22">Ligand binding (Biochemistry)</searchLink><br /><searchLink fieldCode="DE" term="%22Receptor-ligand+complexes%22">Receptor-ligand complexes</searchLink><br /><searchLink fieldCode="DE" term="%22Retinoids%22">Retinoids</searchLink>
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  Label: Abstract
  Group: Ab
  Data: Discusses the study which analyzed the crystal structure of ligand-binding domain (LBD) of human retinoid receptor, RXR-alpha for 9-cis retinoic acid. Dimeric packing of fold of anatiparallel alpha-helical sandwich; Homodimerization of RXR-alpha and LBD; Interaction of 9-cis retinoic acid with transactivation function AF-2; Prototype structure of fold.
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        Value: 10.1038/375377a0
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      – Code: eng
        Text: English
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        PageCount: 6
        StartPage: 377
    Subjects:
      – SubjectFull: Ligand binding (Biochemistry)
        Type: general
      – SubjectFull: Receptor-ligand complexes
        Type: general
      – SubjectFull: Retinoids
        Type: general
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      – TitleFull: Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha.
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            NameFull: Bourguet, William
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            NameFull: Ruff, Marc
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            – D: 01
              M: 06
              Text: 6/1/1995
              Type: published
              Y: 1995
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              Value: 375
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              Value: 6530
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