Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha.
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| Title: | Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha. |
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| Authors: | Bourguet, William, Ruff, Marc |
| Source: | Nature. 6/1/1995, Vol. 375 Issue 6530, p377. 6p. 14 Color Photographs, 3 Diagrams. |
| Subjects: | Ligand binding (Biochemistry), Receptor-ligand complexes, Retinoids |
| Abstract: | Discusses the study which analyzed the crystal structure of ligand-binding domain (LBD) of human retinoid receptor, RXR-alpha for 9-cis retinoic acid. Dimeric packing of fold of anatiparallel alpha-helical sandwich; Homodimerization of RXR-alpha and LBD; Interaction of 9-cis retinoic acid with transactivation function AF-2; Prototype structure of fold. |
| Database: | Engineering Source |
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