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Connexins, gap junctions and tissue invasion.

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Title:	Connexins, gap junctions and tissue invasion.
Authors:	Defamie, Norah¹ norah.defamie@univ-poitiers.fr, Chepied, Amandine¹ amandine.chepied@univ-poitiers.fr, Mesnil, Marc¹ marc.mesnil@univ-poitiers.fr
Source:	FEBS Letters. Apr2014, Vol. 588 Issue 8, p1331-1338. 8p.
Subjects:	Connexins, Gap junctions (Cell biology), Biological invasions, Cancer prognosis, Cancer cells, Cancer invasiveness
Abstract:	Abstract: Formation of metastases negatively impacts the survival prognosis of cancer patients. Globally, if the various steps involved in their formation are relatively well identified, the molecular mechanisms responsible for the emergence of invasive cancer cells are still incompletely resolved. Elucidating what are the mechanisms that allow cancer cells to evade from the tumor is a crucial point since it is the first step of the metastatic potential of a solid tumor. In order to be invasive, cancer cells have to undergo transformations such as down-regulation of cell-cell adhesions, modification of cell-matrix adhesions and acquisition of proteolytic properties. These transformations are accompanied by the capacity to “activate” stromal cells, which may favor the motility of the invasive cells through the extracellular matrix. Since modulation of gap junctional intercellular communication is known to be involved in cancer, we were interested to consider whether these different transformations necessary for the acquisition of invasive phenotype are related with gap junctions and their structural proteins, the connexins. In this review, emerging roles of connexins and gap junctions in the process of tissue invasion are proposed. [Copyright &y& Elsevier]
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Database:	Engineering Source

Description
Abstract:	Abstract: Formation of metastases negatively impacts the survival prognosis of cancer patients. Globally, if the various steps involved in their formation are relatively well identified, the molecular mechanisms responsible for the emergence of invasive cancer cells are still incompletely resolved. Elucidating what are the mechanisms that allow cancer cells to evade from the tumor is a crucial point since it is the first step of the metastatic potential of a solid tumor. In order to be invasive, cancer cells have to undergo transformations such as down-regulation of cell-cell adhesions, modification of cell-matrix adhesions and acquisition of proteolytic properties. These transformations are accompanied by the capacity to “activate” stromal cells, which may favor the motility of the invasive cells through the extracellular matrix. Since modulation of gap junctional intercellular communication is known to be involved in cancer, we were interested to consider whether these different transformations necessary for the acquisition of invasive phenotype are related with gap junctions and their structural proteins, the connexins. In this review, emerging roles of connexins and gap junctions in the process of tissue invasion are proposed. [Copyright &y& Elsevier]
ISSN:	00145793
DOI:	10.1016/j.febslet.2014.01.012