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Connexins, gap junctions and tissue invasion.

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Title: Connexins, gap junctions and tissue invasion.
Authors: Defamie, Norah1 norah.defamie@univ-poitiers.fr, Chepied, Amandine1 amandine.chepied@univ-poitiers.fr, Mesnil, Marc1 marc.mesnil@univ-poitiers.fr
Source: FEBS Letters. Apr2014, Vol. 588 Issue 8, p1331-1338. 8p.
Subjects: Connexins, Gap junctions (Cell biology), Biological invasions, Cancer prognosis, Cancer cells, Cancer invasiveness
Abstract: Abstract: Formation of metastases negatively impacts the survival prognosis of cancer patients. Globally, if the various steps involved in their formation are relatively well identified, the molecular mechanisms responsible for the emergence of invasive cancer cells are still incompletely resolved. Elucidating what are the mechanisms that allow cancer cells to evade from the tumor is a crucial point since it is the first step of the metastatic potential of a solid tumor. In order to be invasive, cancer cells have to undergo transformations such as down-regulation of cell-cell adhesions, modification of cell-matrix adhesions and acquisition of proteolytic properties. These transformations are accompanied by the capacity to “activate” stromal cells, which may favor the motility of the invasive cells through the extracellular matrix. Since modulation of gap junctional intercellular communication is known to be involved in cancer, we were interested to consider whether these different transformations necessary for the acquisition of invasive phenotype are related with gap junctions and their structural proteins, the connexins. In this review, emerging roles of connexins and gap junctions in the process of tissue invasion are proposed. [Copyright &y& Elsevier]
Copyright of FEBS Letters is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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PubType: Academic Journal
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  Data: Connexins, gap junctions and tissue invasion.
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  Data: <searchLink fieldCode="JN" term="%22FEBS+Letters%22">FEBS Letters</searchLink>. Apr2014, Vol. 588 Issue 8, p1331-1338. 8p.
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  Data: <searchLink fieldCode="DE" term="%22Connexins%22">Connexins</searchLink><br /><searchLink fieldCode="DE" term="%22Gap+junctions+%28Cell+biology%29%22">Gap junctions (Cell biology)</searchLink><br /><searchLink fieldCode="DE" term="%22Biological+invasions%22">Biological invasions</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+prognosis%22">Cancer prognosis</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+cells%22">Cancer cells</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+invasiveness%22">Cancer invasiveness</searchLink>
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  Data: Abstract: Formation of metastases negatively impacts the survival prognosis of cancer patients. Globally, if the various steps involved in their formation are relatively well identified, the molecular mechanisms responsible for the emergence of invasive cancer cells are still incompletely resolved. Elucidating what are the mechanisms that allow cancer cells to evade from the tumor is a crucial point since it is the first step of the metastatic potential of a solid tumor. In order to be invasive, cancer cells have to undergo transformations such as down-regulation of cell-cell adhesions, modification of cell-matrix adhesions and acquisition of proteolytic properties. These transformations are accompanied by the capacity to “activate” stromal cells, which may favor the motility of the invasive cells through the extracellular matrix. Since modulation of gap junctional intercellular communication is known to be involved in cancer, we were interested to consider whether these different transformations necessary for the acquisition of invasive phenotype are related with gap junctions and their structural proteins, the connexins. In this review, emerging roles of connexins and gap junctions in the process of tissue invasion are proposed. [Copyright &y& Elsevier]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of FEBS Letters is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=95501099
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        Value: 10.1016/j.febslet.2014.01.012
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      – Code: eng
        Text: English
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        PageCount: 8
        StartPage: 1331
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      – SubjectFull: Connexins
        Type: general
      – SubjectFull: Gap junctions (Cell biology)
        Type: general
      – SubjectFull: Biological invasions
        Type: general
      – SubjectFull: Cancer prognosis
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      – SubjectFull: Cancer cells
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      – SubjectFull: Cancer invasiveness
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      – TitleFull: Connexins, gap junctions and tissue invasion.
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              Text: Apr2014
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