Bibliographic Details
| Title: |
IL-15Rα expression on CD8[sup +] T cells is dispensable for T cell memory. |
| Authors: |
Burkett, Patrick R., Koka, Rima, Chien, Marcia, Chai, Sophia, Chan, Faye, Ma, Averil, Boone, David L. |
| Source: |
Proceedings of the National Academy of Sciences of the United States of America. 4/15/2003, Vol. 100 Issue 8, p4724. 6p. 3 Diagrams, 11 Graphs. |
| Subjects: |
Immunologic memory, T cells, Antigens |
| Abstract: |
The generation and maintenance of immunological memory requires the activation, expansion, and persistent proliferation of antigen-specific T cells. Recent work suggests that IL-15 may be important for this process. Surprisingly, we now find that expression of the high-affinity receptor for IL-15, IL-15Rα, on T cells is dispensable for the generation or maintenance of memory CD8[sup +] T cells. By contrast, IL-15Rα expression on cells other than T cells is absolutely critical for this function. These findings may be related to IL-15Rα's ability to present IL-15 in trans to low-affinity IL15Rβ/γ[sub c] receptors on memory CD8[sup +] T cells. These unexpected results provide insights into how IL-15Rα supports memory CD8[sup +] T cells. [ABSTRACT FROM AUTHOR] |
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| Database: |
Engineering Source |
