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IL-15Rα expression on CD8[sup +] T cells is dispensable for T cell memory.

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Title: IL-15Rα expression on CD8[sup +] T cells is dispensable for T cell memory.
Authors: Burkett, Patrick R., Koka, Rima, Chien, Marcia, Chai, Sophia, Chan, Faye, Ma, Averil, Boone, David L.
Source: Proceedings of the National Academy of Sciences of the United States of America. 4/15/2003, Vol. 100 Issue 8, p4724. 6p. 3 Diagrams, 11 Graphs.
Subjects: Immunologic memory, T cells, Antigens
Abstract: The generation and maintenance of immunological memory requires the activation, expansion, and persistent proliferation of antigen-specific T cells. Recent work suggests that IL-15 may be important for this process. Surprisingly, we now find that expression of the high-affinity receptor for IL-15, IL-15Rα, on T cells is dispensable for the generation or maintenance of memory CD8[sup +] T cells. By contrast, IL-15Rα expression on cells other than T cells is absolutely critical for this function. These findings may be related to IL-15Rα's ability to present IL-15 in trans to low-affinity IL15Rβ/γ[sub c] receptors on memory CD8[sup +] T cells. These unexpected results provide insights into how IL-15Rα supports memory CD8[sup +] T cells. [ABSTRACT FROM AUTHOR]
Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: IL-15Rα expression on CD8[sup +] T cells is dispensable for T cell memory.
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  Data: <searchLink fieldCode="AR" term="%22Burkett%2C+Patrick+R%2E%22">Burkett, Patrick R.</searchLink><br /><searchLink fieldCode="AR" term="%22Koka%2C+Rima%22">Koka, Rima</searchLink><br /><searchLink fieldCode="AR" term="%22Chien%2C+Marcia%22">Chien, Marcia</searchLink><br /><searchLink fieldCode="AR" term="%22Chai%2C+Sophia%22">Chai, Sophia</searchLink><br /><searchLink fieldCode="AR" term="%22Chan%2C+Faye%22">Chan, Faye</searchLink><br /><searchLink fieldCode="AR" term="%22Ma%2C+Averil%22">Ma, Averil</searchLink><br /><searchLink fieldCode="AR" term="%22Boone%2C+David+L%2E%22">Boone, David L.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink>. 4/15/2003, Vol. 100 Issue 8, p4724. 6p. 3 Diagrams, 11 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Immunologic+memory%22">Immunologic memory</searchLink><br /><searchLink fieldCode="DE" term="%22T+cells%22">T cells</searchLink><br /><searchLink fieldCode="DE" term="%22Antigens%22">Antigens</searchLink>
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  Label: Abstract
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  Data: The generation and maintenance of immunological memory requires the activation, expansion, and persistent proliferation of antigen-specific T cells. Recent work suggests that IL-15 may be important for this process. Surprisingly, we now find that expression of the high-affinity receptor for IL-15, IL-15Rα, on T cells is dispensable for the generation or maintenance of memory CD8[sup +] T cells. By contrast, IL-15Rα expression on cells other than T cells is absolutely critical for this function. These findings may be related to IL-15Rα's ability to present IL-15 in trans to low-affinity IL15Rβ/γ[sub c] receptors on memory CD8[sup +] T cells. These unexpected results provide insights into how IL-15Rα supports memory CD8[sup +] T cells. [ABSTRACT FROM AUTHOR]
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  Label:
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  Data: <i>Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Text: English
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              Text: 4/15/2003
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