Diastereofacial selective addition of ethynylcerium reagent and Barton-McCombie reaction as the...

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Bibliographic Details
Title: Diastereofacial selective addition of ethynylcerium reagent and Barton-McCombie reaction as the...
Authors: Jung, Pierre M. J., Burger, Alain
Source: Journal of Organic Chemistry. 11/28/97, Vol. 62 Issue 24, p8309. 6p.
Subjects: Adenosines
Abstract: Presents a study which describes the preparation of 3'-alkynyluridine and -adenosine and of 3'-alkynyl-2'-deoxyuridine and -adenosinr starting from the corresponding nucleasides. Evaluation of the anti-HIV activity of the C-3 modified nucleosides; General procedure for the selective deprotection of 2', 5'-O-Bis-TBDMS-ketonucleosides; Disadvantage of this approach; Results of the study.
Database: Engineering Source
Description
Abstract:Presents a study which describes the preparation of 3'-alkynyluridine and -adenosine and of 3'-alkynyl-2'-deoxyuridine and -adenosinr starting from the corresponding nucleasides. Evaluation of the anti-HIV activity of the C-3 modified nucleosides; General procedure for the selective deprotection of 2', 5'-O-Bis-TBDMS-ketonucleosides; Disadvantage of this approach; Results of the study.
ISSN:00223263
DOI:10.1021/jo9704568