Small molecule interactions with protein-tyrosine phosphatase PTP1B and their use in inhibitor...
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| Title: | Small molecule interactions with protein-tyrosine phosphatase PTP1B and their use in inhibitor... |
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| Authors: | Burke Jr., Terrence R., Ye, Bin |
| Source: | Biochemistry. 12/17/96, Vol. 35 Issue 50, p15989. 8p. 5 Color Photographs, 3 Diagrams, 3 Charts. |
| Subjects: | Phosphatases, Chemical inhibitors |
| Abstract: | Examines the small molecule interactions with protein-tyrosine phosphatase PTP1B and their use in inhibitor design. Indications that the introduction of a hydroxyl could enhance binding interactions; Determination of the X-ray structure of the PTP1B complex; Revelation of the extensive hydrophobic interactions with the naphthalene system. |
| Database: | Engineering Source |
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