Comparison of dual-biomarker PIB-PET and dual-tracer PET in AD diagnosis.
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| Title: | Comparison of dual-biomarker PIB-PET and dual-tracer PET in AD diagnosis. |
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| Authors: | Fu, Liping1, Liu, Linwen2, Zhang, Jinming1, Xu, Baixuan1, Fan, Yong2, Tian, Jiahe1 tianjh@vip.sina.com |
| Source: | European Radiology. Nov2014, Vol. 24 Issue 11, p2800-2809. 10p. |
| Subjects: | Biomarkers, Alzheimer's disease diagnosis, Amyloid plaque, Mild cognitive impairment, Medical imaging systems |
| Abstract: | Objectives: To identify the optimal time window for capturing perfusion information from early C-PIB imaging frames (perfusion PIB, C-pPIB) and to compare the performance of F-FDG PET and "dual biomarker" C-PIB PET [C-pPIB and amyloid PIB (C-aPIB)] for classification of AD, MCI and CN subjects. Methods: Forty subjects (14 CN, 12 MCI and 14 AD patients) underwent F-FDG and C-PIB PET studies. Pearson correlation between the F-FDG image and sum of early C-PIB frames was maximised to identify the optimal time window for C-pPIB. The classification power of imaging parameters was evaluated with a leave-one-out validation. Results: A 7-min time window yielded the highest correlation between F-FDG and C-pPIB. C-pPIB and F-FDG images shared a similar radioactive distribution pattern. F-FDG performed better than C-pPIB for the classification of both AD vs. CN and MCI vs. CN. C-pPIB + C-aPIB and F-FDG + C-aPIB yielded the highest classification accuracy for the classification of AD vs. CN, and F-FDG + C-aPIB had the best classification performance for the classification of MCI vs. CN. Conclusion: C-pPIB could serve as a useful biomarker of rCBF for measuring neural activity and improve the diagnostic power of PET for AD in conjunction with C-aPIB. F-FDG and C-PIB dual-tracer PET examination could better detect MCI. Key Points: • Dual-tracer PET examination provides neurofunctional and neuropathological information for AD diagnosis. • The identified optimal 11C-pPIB time frames had highest correlation with 18F-FDG. • 11C-pPIB images shared a similar radioactive distribution pattern with 18F-FDG images. • 11C-pPIB can provide neurofunctional information. • Dual-tracer PET examination could better detect MCI. [ABSTRACT FROM AUTHOR] |
| Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 98625335 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Comparison of dual-biomarker PIB-PET and dual-tracer PET in AD diagnosis. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Fu%2C+Liping%22">Fu, Liping</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Liu%2C+Linwen%22">Liu, Linwen</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Zhang%2C+Jinming%22">Zhang, Jinming</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Xu%2C+Baixuan%22">Xu, Baixuan</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Fan%2C+Yong%22">Fan, Yong</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Tian%2C+Jiahe%22">Tian, Jiahe</searchLink><relatesTo>1</relatesTo><i> tianjh@vip.sina.com</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Radiology%22">European Radiology</searchLink>. Nov2014, Vol. 24 Issue 11, p2800-2809. 10p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Biomarkers%22">Biomarkers</searchLink><br /><searchLink fieldCode="DE" term="%22Alzheimer's+disease+diagnosis%22">Alzheimer's disease diagnosis</searchLink><br /><searchLink fieldCode="DE" term="%22Amyloid+plaque%22">Amyloid plaque</searchLink><br /><searchLink fieldCode="DE" term="%22Mild+cognitive+impairment%22">Mild cognitive impairment</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+imaging+systems%22">Medical imaging systems</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Objectives: To identify the optimal time window for capturing perfusion information from early C-PIB imaging frames (perfusion PIB, C-pPIB) and to compare the performance of F-FDG PET and "dual biomarker" C-PIB PET [C-pPIB and amyloid PIB (C-aPIB)] for classification of AD, MCI and CN subjects. Methods: Forty subjects (14 CN, 12 MCI and 14 AD patients) underwent F-FDG and C-PIB PET studies. Pearson correlation between the F-FDG image and sum of early C-PIB frames was maximised to identify the optimal time window for C-pPIB. The classification power of imaging parameters was evaluated with a leave-one-out validation. Results: A 7-min time window yielded the highest correlation between F-FDG and C-pPIB. C-pPIB and F-FDG images shared a similar radioactive distribution pattern. F-FDG performed better than C-pPIB for the classification of both AD vs. CN and MCI vs. CN. C-pPIB + C-aPIB and F-FDG + C-aPIB yielded the highest classification accuracy for the classification of AD vs. CN, and F-FDG + C-aPIB had the best classification performance for the classification of MCI vs. CN. Conclusion: C-pPIB could serve as a useful biomarker of rCBF for measuring neural activity and improve the diagnostic power of PET for AD in conjunction with C-aPIB. F-FDG and C-PIB dual-tracer PET examination could better detect MCI. Key Points: • Dual-tracer PET examination provides neurofunctional and neuropathological information for AD diagnosis. • The identified optimal 11C-pPIB time frames had highest correlation with 18F-FDG. • 11C-pPIB images shared a similar radioactive distribution pattern with 18F-FDG images. • 11C-pPIB can provide neurofunctional information. • Dual-tracer PET examination could better detect MCI. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00330-014-3311-x Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 10 StartPage: 2800 Subjects: – SubjectFull: Biomarkers Type: general – SubjectFull: Alzheimer's disease diagnosis Type: general – SubjectFull: Amyloid plaque Type: general – SubjectFull: Mild cognitive impairment Type: general – SubjectFull: Medical imaging systems Type: general Titles: – TitleFull: Comparison of dual-biomarker PIB-PET and dual-tracer PET in AD diagnosis. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Fu, Liping – PersonEntity: Name: NameFull: Liu, Linwen – PersonEntity: Name: NameFull: Zhang, Jinming – PersonEntity: Name: NameFull: Xu, Baixuan – PersonEntity: Name: NameFull: Fan, Yong – PersonEntity: Name: NameFull: Tian, Jiahe IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 11 Text: Nov2014 Type: published Y: 2014 Identifiers: – Type: issn-print Value: 09387994 Numbering: – Type: volume Value: 24 – Type: issue Value: 11 Titles: – TitleFull: European Radiology Type: main |
| ResultId | 1 |
