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Serum S-100ß response to exercise-heat strain before and after acclimation.

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Title: Serum S-100ß response to exercise-heat strain before and after acclimation.
Authors: Cheuvront SN (AUTHOR), Chinevere TD (AUTHOR), Ely BR (AUTHOR), Kenefick RW (AUTHOR), Goodman DA (AUTHOR), McClung JP (AUTHOR), Sawka MN (AUTHOR)
Source: Medicine & Science in Sports & Exercise. Aug2008, Vol. 40 Issue 8, p1477-1482. 6p.
Abstract: Exercise alone or in combination with environmental heat stress can elevate blood S-100beta protein concentrations. However, the explanatory power of exercise with marked environmental heat stress on the appearance of S-100beta is questionable. It is possible that the process of heat acclimation might afford additional insight. PURPOSE:: Determine the S-100beta response to moderate-intensity exercise with heat strain before and after heat acclimation. METHODS:: Nine healthy male volunteers completed 10 consecutive days of heat acclimation consisting of up to 100 min of treadmill walking (1.56 m.s, 4% grade) in the heat (45 degrees C, 20% relative humidity). Changes in HR, rectal temperature (Tre), and sweat rate (SR) were examined to determine successful acclimation. Area under the curve (AUC) for Tre greater than 38.5 degrees C was calculated to assess cumulative hyperthermia. Blood samples were taken before and after exercise on days 1 and 10 and were analyzed for serum osmolality and S-100beta concentration. RESULTS:: All subjects displayed physiological adaptations to heat acclimation including a significant (P < 0.05) reduction in final HR (161 to 145 bpm) and Tre (39.0 to 38.4 degrees C), as well as a modest ( 10%) increase in SR (1.10 to 1.20 L.h; P = 0.09). No differences were observed in pre- to postexercise serum S-100beta concentrations on day 1 or 10, and no differences were observed in S-100beta values between days 1 and 10. No significant correlations were found between S-100beta values and any variable of interest. CONCLUSIONS:: S-100beta concentrations do not necessarily increase in response to exercise-heat strain, and no effect of heat acclimation on S-100beta could be observed despite other quantifiable physiological adaptations. [ABSTRACT FROM AUTHOR]
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Database: Education Research Complete
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Abstract:Exercise alone or in combination with environmental heat stress can elevate blood S-100beta protein concentrations. However, the explanatory power of exercise with marked environmental heat stress on the appearance of S-100beta is questionable. It is possible that the process of heat acclimation might afford additional insight. PURPOSE:: Determine the S-100beta response to moderate-intensity exercise with heat strain before and after heat acclimation. METHODS:: Nine healthy male volunteers completed 10 consecutive days of heat acclimation consisting of up to 100 min of treadmill walking (1.56 m.s, 4% grade) in the heat (45 degrees C, 20% relative humidity). Changes in HR, rectal temperature (Tre), and sweat rate (SR) were examined to determine successful acclimation. Area under the curve (AUC) for Tre greater than 38.5 degrees C was calculated to assess cumulative hyperthermia. Blood samples were taken before and after exercise on days 1 and 10 and were analyzed for serum osmolality and S-100beta concentration. RESULTS:: All subjects displayed physiological adaptations to heat acclimation including a significant (P < 0.05) reduction in final HR (161 to 145 bpm) and Tre (39.0 to 38.4 degrees C), as well as a modest ( 10%) increase in SR (1.10 to 1.20 L.h; P = 0.09). No differences were observed in pre- to postexercise serum S-100beta concentrations on day 1 or 10, and no differences were observed in S-100beta values between days 1 and 10. No significant correlations were found between S-100beta values and any variable of interest. CONCLUSIONS:: S-100beta concentrations do not necessarily increase in response to exercise-heat strain, and no effect of heat acclimation on S-100beta could be observed despite other quantifiable physiological adaptations. [ABSTRACT FROM AUTHOR]
ISSN:01959131
DOI:10.1249/mss.0b013e31816d65a5