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Effect of Beta-Alanine and Carnosine Supplementation on Muscle Contractility in Mice.

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Bibliographic Details
Title: Effect of Beta-Alanine and Carnosine Supplementation on Muscle Contractility in Mice.
Authors: EVERAERT, INGE1 (AUTHOR), STEGEN, SANNE1 (AUTHOR), VANHEEL, BERT2 (AUTHOR), TAES, YORUI3 (AUTHOR), DERAVE, WIM1 (AUTHOR) Wim.derave@ugent.be
Source: Medicine & Science in Sports & Exercise. Jan2013, Vol. 45 Issue 1, p43-51. 9p. 1 Diagram, 2 Charts, 3 Graphs.
Subject Terms: *Statistical correlation, *Data analysis, Alanine, Amino acids, Analysis of variance, Animal experimentation, Biological models, Dietary supplements, Mice, Muscle contraction, Research funding, Statistics, T-test (Statistics), Descriptive statistics
Abstract: The article reports on research which was conducted to investigate the effect long-term supplementation with increasing doses of camosine and beta-alanine had on muscle camosine, anserine, and taurine levels and on in vitro contractility and fatigue in mice. Researchers evaluated 66 male Naval Medical Research Institute mice who were control fed or supplemented with either camosine or beta-alanine in their drinking water for 8-12 weeks. They found that beta-alanine availability seemed to be the rate-limiting step for synthesis of muscle histidine-containing dipeptides in mice and that muscle histidine-containing dipeptide loading in mice moderately and muscle dependently affected excitation-contraction coupling and fatigue.
Database: Education Research Complete
Description
Abstract:The article reports on research which was conducted to investigate the effect long-term supplementation with increasing doses of camosine and beta-alanine had on muscle camosine, anserine, and taurine levels and on in vitro contractility and fatigue in mice. Researchers evaluated 66 male Naval Medical Research Institute mice who were control fed or supplemented with either camosine or beta-alanine in their drinking water for 8-12 weeks. They found that beta-alanine availability seemed to be the rate-limiting step for synthesis of muscle histidine-containing dipeptides in mice and that muscle histidine-containing dipeptide loading in mice moderately and muscle dependently affected excitation-contraction coupling and fatigue.
ISSN:01959131
DOI:10.1249/MSS.0b013e31826cdb68