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Effect of Beta-Alanine and Carnosine Supplementation on Muscle Contractility in Mice.

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Title: Effect of Beta-Alanine and Carnosine Supplementation on Muscle Contractility in Mice.
Authors: EVERAERT, INGE1 (AUTHOR), STEGEN, SANNE1 (AUTHOR), VANHEEL, BERT2 (AUTHOR), TAES, YORUI3 (AUTHOR), DERAVE, WIM1 (AUTHOR) Wim.derave@ugent.be
Source: Medicine & Science in Sports & Exercise. Jan2013, Vol. 45 Issue 1, p43-51. 9p. 1 Diagram, 2 Charts, 3 Graphs.
Subject Terms: *Statistical correlation, *Data analysis, Alanine, Amino acids, Analysis of variance, Animal experimentation, Biological models, Dietary supplements, Mice, Muscle contraction, Research funding, Statistics, T-test (Statistics), Descriptive statistics
Abstract: The article reports on research which was conducted to investigate the effect long-term supplementation with increasing doses of camosine and beta-alanine had on muscle camosine, anserine, and taurine levels and on in vitro contractility and fatigue in mice. Researchers evaluated 66 male Naval Medical Research Institute mice who were control fed or supplemented with either camosine or beta-alanine in their drinking water for 8-12 weeks. They found that beta-alanine availability seemed to be the rate-limiting step for synthesis of muscle histidine-containing dipeptides in mice and that muscle histidine-containing dipeptide loading in mice moderately and muscle dependently affected excitation-contraction coupling and fatigue.
Database: Education Research Complete
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  Availability: 0
Header DbId: ehh
DbLabel: Education Research Complete
An: 84555620
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Label: Title
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  Data: Effect of Beta-Alanine and Carnosine Supplementation on Muscle Contractility in Mice.
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  Data: <searchLink fieldCode="AR" term="%22EVERAERT%2C+INGE%22">EVERAERT, INGE</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22STEGEN%2C+SANNE%22">STEGEN, SANNE</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22VANHEEL%2C+BERT%22">VANHEEL, BERT</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22TAES%2C+YORUI%22">TAES, YORUI</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22DERAVE%2C+WIM%22">DERAVE, WIM</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> Wim.derave@ugent.be</i>
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  Data: <searchLink fieldCode="JN" term="%22Medicine+%26+Science+in+Sports+%26+Exercise%22">Medicine & Science in Sports & Exercise</searchLink>. Jan2013, Vol. 45 Issue 1, p43-51. 9p. 1 Diagram, 2 Charts, 3 Graphs.
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: *<searchLink fieldCode="DE" term="%22Statistical+correlation%22">Statistical correlation</searchLink><br />*<searchLink fieldCode="DE" term="%22Data+analysis%22">Data analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Alanine%22">Alanine</searchLink><br /><searchLink fieldCode="DE" term="%22Amino+acids%22">Amino acids</searchLink><br /><searchLink fieldCode="DE" term="%22Analysis+of+variance%22">Analysis of variance</searchLink><br /><searchLink fieldCode="DE" term="%22Animal+experimentation%22">Animal experimentation</searchLink><br /><searchLink fieldCode="DE" term="%22Biological+models%22">Biological models</searchLink><br /><searchLink fieldCode="DE" term="%22Dietary+supplements%22">Dietary supplements</searchLink><br /><searchLink fieldCode="DE" term="%22Mice%22">Mice</searchLink><br /><searchLink fieldCode="DE" term="%22Muscle+contraction%22">Muscle contraction</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Statistics%22">Statistics</searchLink><br /><searchLink fieldCode="DE" term="%22T-test+%28Statistics%29%22">T-test (Statistics)</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The article reports on research which was conducted to investigate the effect long-term supplementation with increasing doses of camosine and beta-alanine had on muscle camosine, anserine, and taurine levels and on in vitro contractility and fatigue in mice. Researchers evaluated 66 male Naval Medical Research Institute mice who were control fed or supplemented with either camosine or beta-alanine in their drinking water for 8-12 weeks. They found that beta-alanine availability seemed to be the rate-limiting step for synthesis of muscle histidine-containing dipeptides in mice and that muscle histidine-containing dipeptide loading in mice moderately and muscle dependently affected excitation-contraction coupling and fatigue.
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=ehh&AN=84555620
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1249/MSS.0b013e31826cdb68
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 9
        StartPage: 43
    Subjects:
      – SubjectFull: Statistical correlation
        Type: general
      – SubjectFull: Data analysis
        Type: general
      – SubjectFull: Alanine
        Type: general
      – SubjectFull: Amino acids
        Type: general
      – SubjectFull: Analysis of variance
        Type: general
      – SubjectFull: Animal experimentation
        Type: general
      – SubjectFull: Biological models
        Type: general
      – SubjectFull: Dietary supplements
        Type: general
      – SubjectFull: Mice
        Type: general
      – SubjectFull: Muscle contraction
        Type: general
      – SubjectFull: Research funding
        Type: general
      – SubjectFull: Statistics
        Type: general
      – SubjectFull: T-test (Statistics)
        Type: general
      – SubjectFull: Descriptive statistics
        Type: general
    Titles:
      – TitleFull: Effect of Beta-Alanine and Carnosine Supplementation on Muscle Contractility in Mice.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: EVERAERT, INGE
      – PersonEntity:
          Name:
            NameFull: STEGEN, SANNE
      – PersonEntity:
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            NameFull: VANHEEL, BERT
      – PersonEntity:
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            NameFull: TAES, YORUI
      – PersonEntity:
          Name:
            NameFull: DERAVE, WIM
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            – D: 01
              M: 01
              Text: Jan2013
              Type: published
              Y: 2013
          Identifiers:
            – Type: issn-print
              Value: 01959131
          Numbering:
            – Type: volume
              Value: 45
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Medicine & Science in Sports & Exercise
              Type: main
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