View in EDS HTML Full Text PDF Full Text

Sericin stabilized emulgel for improving therapeutic efficacy of quercetin in treatment of diabetic wound healing.

Saved in:
Bibliographic Details
Title: Sericin stabilized emulgel for improving therapeutic efficacy of quercetin in treatment of diabetic wound healing.
Authors: Burud, Asmita1 (AUTHOR), Galatage, Sunil2 (AUTHOR) gsunil201288@gmail.com, Manjappa, Arehalli2 (AUTHOR), Salawi, Ahmad3 (AUTHOR), Nadaf, Sameer4 (AUTHOR) sam.nadaf@rediffmail.com, Holam, Machindra1 (AUTHOR), Harale, Swapnil1 (AUTHOR), Kumbhar, Ravindra5 (AUTHOR), Peram, Malleswara Rao6 (AUTHOR), Suryadevara, Vidyadhara6 (AUTHOR)
Source: Journal of Dispersion Science & Technology. 2026, Vol. 47 Issue 7, p1400-1420. 21p.
Subject Terms: *Quercetin, *Colloidal stability, *Zeta potential, *Treatment effectiveness, *Olive oil, *In vitro toxicity testing, *Diabetic foot
Abstract: Emulsion stability is vital for effectiveness, ensuring uniform distribution of droplets and preventing phase separation. Instability can lead to inconsistent performance and reduced therapeutic benefits. Thus, our research endeavors were directed toward the design and characterization of a sericin (SN) stabilized quercetin (QRN) emulgel (EG), specifically tailored for diabetic wound healing. Employing a two-factor, 3-level factorial design SN-stabilized QRN emulgel (QSEG) was prepared and the influence of varying percentages of olive oil and SN on zeta potential, globule size, and entrapment efficiency (%) was scrutinized. The optimized QRN emulgel (QSEG), composed of 10% oil and 5% SN (QSE-6), showcased a diminutive globule size of 809.2 ± 21.3 nm alongside an elevated zeta potential of −42.9 ± 3.79 mV. Submicron-sized spherical globules were observed without any signs of coalescence, confirmed by surface morphology analysis. FTIR showed compatibility, while DSC and XRD confirmed that QRN was amorphized and evenly dispersed within the emulgel. In-vitro scratch assays manifested reduced intercellular distances and wound closure, indicative of potent wound healing attributes of QSEG. QSEG demonstrated notable antibacterial efficacy against Escherichia coli (E. coli), with minimum inhibitory concentrations (MIC) and minimum bactericidal concentrations (MBC) of 3.125 ± 0.4 and 6.25 ± 1.2 μg/mL, respectively, surpassing that against Staphylococcus aureus (S.aureus). Cytotoxicity assays evidenced diminished toxicity toward fibroblast cells. Furthermore, in-vivo wound healing studies unveiled significant (p ˂ 0.001) enhancements with QSEG compared to QRN-treated and control groups. Our findings underscore SN's role as a natural stabilizer, synergistically enhancing QSEG's diabetic wound healing potential. Conclusively, QSEG emerges as a promising alternative to conventional diabetic wound healing treatments, offering inherent medicinal benefits. [ABSTRACT FROM AUTHOR]
Database: Energy & Power Source
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: enr
DbLabel: Energy & Power Source
An: 193754424
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Sericin stabilized emulgel for improving therapeutic efficacy of quercetin in treatment of diabetic wound healing.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Burud%2C+Asmita%22">Burud, Asmita</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Galatage%2C+Sunil%22">Galatage, Sunil</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> gsunil201288@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Manjappa%2C+Arehalli%22">Manjappa, Arehalli</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Salawi%2C+Ahmad%22">Salawi, Ahmad</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nadaf%2C+Sameer%22">Nadaf, Sameer</searchLink><relatesTo>4</relatesTo> (AUTHOR)<i> sam.nadaf@rediffmail.com</i><br /><searchLink fieldCode="AR" term="%22Holam%2C+Machindra%22">Holam, Machindra</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Harale%2C+Swapnil%22">Harale, Swapnil</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kumbhar%2C+Ravindra%22">Kumbhar, Ravindra</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Peram%2C+Malleswara+Rao%22">Peram, Malleswara Rao</searchLink><relatesTo>6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Suryadevara%2C+Vidyadhara%22">Suryadevara, Vidyadhara</searchLink><relatesTo>6</relatesTo> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Journal+of+Dispersion+Science+%26+Technology%22">Journal of Dispersion Science & Technology</searchLink>. 2026, Vol. 47 Issue 7, p1400-1420. 21p.
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: *<searchLink fieldCode="DE" term="%22Quercetin%22">Quercetin</searchLink><br />*<searchLink fieldCode="DE" term="%22Colloidal+stability%22">Colloidal stability</searchLink><br />*<searchLink fieldCode="DE" term="%22Zeta+potential%22">Zeta potential</searchLink><br />*<searchLink fieldCode="DE" term="%22Treatment+effectiveness%22">Treatment effectiveness</searchLink><br />*<searchLink fieldCode="DE" term="%22Olive+oil%22">Olive oil</searchLink><br />*<searchLink fieldCode="DE" term="%22In+vitro+toxicity+testing%22">In vitro toxicity testing</searchLink><br />*<searchLink fieldCode="DE" term="%22Diabetic+foot%22">Diabetic foot</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Emulsion stability is vital for effectiveness, ensuring uniform distribution of droplets and preventing phase separation. Instability can lead to inconsistent performance and reduced therapeutic benefits. Thus, our research endeavors were directed toward the design and characterization of a sericin (SN) stabilized quercetin (QRN) emulgel (EG), specifically tailored for diabetic wound healing. Employing a two-factor, 3-level factorial design SN-stabilized QRN emulgel (QSEG) was prepared and the influence of varying percentages of olive oil and SN on zeta potential, globule size, and entrapment efficiency (%) was scrutinized. The optimized QRN emulgel (QSEG), composed of 10% oil and 5% SN (QSE-6), showcased a diminutive globule size of 809.2 ± 21.3 nm alongside an elevated zeta potential of −42.9 ± 3.79 mV. Submicron-sized spherical globules were observed without any signs of coalescence, confirmed by surface morphology analysis. FTIR showed compatibility, while DSC and XRD confirmed that QRN was amorphized and evenly dispersed within the emulgel. In-vitro scratch assays manifested reduced intercellular distances and wound closure, indicative of potent wound healing attributes of QSEG. QSEG demonstrated notable antibacterial efficacy against Escherichia coli (E. coli), with minimum inhibitory concentrations (MIC) and minimum bactericidal concentrations (MBC) of 3.125 ± 0.4 and 6.25 ± 1.2 μg/mL, respectively, surpassing that against Staphylococcus aureus (S.aureus). Cytotoxicity assays evidenced diminished toxicity toward fibroblast cells. Furthermore, in-vivo wound healing studies unveiled significant (p ˂ 0.001) enhancements with QSEG compared to QRN-treated and control groups. Our findings underscore SN's role as a natural stabilizer, synergistically enhancing QSEG's diabetic wound healing potential. Conclusively, QSEG emerges as a promising alternative to conventional diabetic wound healing treatments, offering inherent medicinal benefits. [ABSTRACT FROM AUTHOR]
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=enr&AN=193754424
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/01932691.2024.2444980
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 21
        StartPage: 1400
    Subjects:
      – SubjectFull: Quercetin
        Type: general
      – SubjectFull: Colloidal stability
        Type: general
      – SubjectFull: Zeta potential
        Type: general
      – SubjectFull: Treatment effectiveness
        Type: general
      – SubjectFull: Olive oil
        Type: general
      – SubjectFull: In vitro toxicity testing
        Type: general
      – SubjectFull: Diabetic foot
        Type: general
    Titles:
      – TitleFull: Sericin stabilized emulgel for improving therapeutic efficacy of quercetin in treatment of diabetic wound healing.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Burud, Asmita
      – PersonEntity:
          Name:
            NameFull: Galatage, Sunil
      – PersonEntity:
          Name:
            NameFull: Manjappa, Arehalli
      – PersonEntity:
          Name:
            NameFull: Salawi, Ahmad
      – PersonEntity:
          Name:
            NameFull: Nadaf, Sameer
      – PersonEntity:
          Name:
            NameFull: Holam, Machindra
      – PersonEntity:
          Name:
            NameFull: Harale, Swapnil
      – PersonEntity:
          Name:
            NameFull: Kumbhar, Ravindra
      – PersonEntity:
          Name:
            NameFull: Peram, Malleswara Rao
      – PersonEntity:
          Name:
            NameFull: Suryadevara, Vidyadhara
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 06
              Text: 2026
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-print
              Value: 01932691
          Numbering:
            – Type: volume
              Value: 47
            – Type: issue
              Value: 7
          Titles:
            – TitleFull: Journal of Dispersion Science & Technology
              Type: main
ResultId 1