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The Gluten-Free/Casein-Free Diet: A Double-Blind Challenge Trial in Children with Autism

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Title: The Gluten-Free/Casein-Free Diet: A Double-Blind Challenge Trial in Children with Autism
Language: English
Authors: Hyman, Susan L., Stewart, Patricia A., Foley, Jennifer
Source: Journal of Autism and Developmental Disorders. Jan 2016 46(1):205-220.
Availability: Springer. 233 Spring Street, New York, NY 10013. Tel: 800-777-4643; Tel: 212-460-1500; Fax: 212-348-4505; e-mail: service-ny@springer.com; Web site: http://www.springerlink.com
Peer Reviewed: Y
Page Count: 16
Publication Date: 2016
Document Type: Journal Articles
Reports - Research
Descriptors: Dietetics, Sample Size, Statistical Analysis, Statistical Significance, Behavior Problems, Autism, Symptoms (Individual Disorders), Physiology, Safety, Young Children, Toddlers, Control Groups, Food, Nutrition, Counseling, Correlation, Outcomes of Treatment
DOI: 10.1007/s10803-015-2564-9
ISSN: 0162-3257
Abstract: To obtain information on the safety and efficacy of the gluten-free/casein-free (GFCF) diet, we placed 14 children with autism, age 3-5 years, on the diet for 4-6 weeks and then conducted a double-blind, placebo-controlled challenge study for 12 weeks while continuing the diet, with a 12-week follow-up. Dietary challenges were delivered via weekly snacks that contained gluten, casein, gluten and casein, or placebo. With nutritional counseling, the diet was safe and well-tolerated. However, dietary challenges did not have statistically significant effects on measures of physiologic functioning, behavior problems, or autism symptoms. Although these findings must be interpreted with caution because of the small sample size, the study does not provide evidence to support general use of the GFCF diet.
Abstractor: As Provided
Number of References: 53
Entry Date: 2016
Accession Number: EJ1086641
Database: ERIC
FullText Links:
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  Data: The Gluten-Free/Casein-Free Diet: A Double-Blind Challenge Trial in Children with Autism
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  Data: <searchLink fieldCode="AR" term="%22Hyman%2C+Susan+L%2E%22">Hyman, Susan L.</searchLink><br /><searchLink fieldCode="AR" term="%22Stewart%2C+Patricia+A%2E%22">Stewart, Patricia A.</searchLink><br /><searchLink fieldCode="AR" term="%22Foley%2C+Jennifer%22">Foley, Jennifer</searchLink>
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  Data: <searchLink fieldCode="SO" term="%22Journal+of+Autism+and+Developmental+Disorders%22"><i>Journal of Autism and Developmental Disorders</i></searchLink>. Jan 2016 46(1):205-220.
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  Data: Springer. 233 Spring Street, New York, NY 10013. Tel: 800-777-4643; Tel: 212-460-1500; Fax: 212-348-4505; e-mail: service-ny@springer.com; Web site: http://www.springerlink.com
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  Data: <searchLink fieldCode="DE" term="%22Dietetics%22">Dietetics</searchLink><br /><searchLink fieldCode="DE" term="%22Sample+Size%22">Sample Size</searchLink><br /><searchLink fieldCode="DE" term="%22Statistical+Analysis%22">Statistical Analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Statistical+Significance%22">Statistical Significance</searchLink><br /><searchLink fieldCode="DE" term="%22Behavior+Problems%22">Behavior Problems</searchLink><br /><searchLink fieldCode="DE" term="%22Autism%22">Autism</searchLink><br /><searchLink fieldCode="DE" term="%22Symptoms+%28Individual+Disorders%29%22">Symptoms (Individual Disorders)</searchLink><br /><searchLink fieldCode="DE" term="%22Physiology%22">Physiology</searchLink><br /><searchLink fieldCode="DE" term="%22Safety%22">Safety</searchLink><br /><searchLink fieldCode="DE" term="%22Young+Children%22">Young Children</searchLink><br /><searchLink fieldCode="DE" term="%22Toddlers%22">Toddlers</searchLink><br /><searchLink fieldCode="DE" term="%22Control+Groups%22">Control Groups</searchLink><br /><searchLink fieldCode="DE" term="%22Food%22">Food</searchLink><br /><searchLink fieldCode="DE" term="%22Nutrition%22">Nutrition</searchLink><br /><searchLink fieldCode="DE" term="%22Counseling%22">Counseling</searchLink><br /><searchLink fieldCode="DE" term="%22Correlation%22">Correlation</searchLink><br /><searchLink fieldCode="DE" term="%22Outcomes+of+Treatment%22">Outcomes of Treatment</searchLink>
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  Data: 0162-3257
– Name: Abstract
  Label: Abstract
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  Data: To obtain information on the safety and efficacy of the gluten-free/casein-free (GFCF) diet, we placed 14 children with autism, age 3-5 years, on the diet for 4-6 weeks and then conducted a double-blind, placebo-controlled challenge study for 12 weeks while continuing the diet, with a 12-week follow-up. Dietary challenges were delivered via weekly snacks that contained gluten, casein, gluten and casein, or placebo. With nutritional counseling, the diet was safe and well-tolerated. However, dietary challenges did not have statistically significant effects on measures of physiologic functioning, behavior problems, or autism symptoms. Although these findings must be interpreted with caution because of the small sample size, the study does not provide evidence to support general use of the GFCF diet.
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  Data: 2016
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      – SubjectFull: Dietetics
        Type: general
      – SubjectFull: Sample Size
        Type: general
      – SubjectFull: Statistical Analysis
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      – SubjectFull: Statistical Significance
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      – SubjectFull: Behavior Problems
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      – SubjectFull: Autism
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      – SubjectFull: Safety
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      – SubjectFull: Young Children
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      – SubjectFull: Toddlers
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      – SubjectFull: Control Groups
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      – TitleFull: The Gluten-Free/Casein-Free Diet: A Double-Blind Challenge Trial in Children with Autism
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